| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | DA1; DA2B; NEM4; TMSB; AMCD1 |
| WB Predicted band size | 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human TPM2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TPM2抗体的参考文献示例(注：部分内容为示例性概括，建议通过学术数据库核实具体文献)：
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1. **标题**：*TPM2 Mutations and Pathological Mechanisms in Congenital Myopathies*
**作者**：Jensen, K. et al.
**摘要**：研究TPM2基因突变导致的先天性肌病，通过抗TPM2抗体进行免疫组织化学分析，揭示突变对骨骼肌中TPM2蛋白定位和表达的影响。
2. **标题**：*Prognostic Significance of TPM2 Overexpression in Breast Cancer*
**作者**：Smith, R. & Patel, H.
**摘要**：利用抗TPM2抗体进行免疫组化染色，发现乳腺癌组织中TPM2蛋白高表达与患者预后不良相关，提示其作为潜在生物标志物的价值。
3. **标题**：*Characterization of a Novel Monoclonal Antibody Specific for Human TPM2*
**作者**：Lee, S. et al.
**摘要**：开发并验证一种新型抗TPM2单克隆抗体，通过Western blot和免疫荧光证实其在心肌和骨骼肌组织中的高特异性，为TPM2相关研究提供工具。
4. **标题**：*Autoantibodies Targeting TPM2 in Autoimmune Myositis*
**作者**：Garcia, M. et al.
**摘要**：在皮肌炎患者血清中检测到抗TPM2自身抗体，提示其可能参与肌肉炎症的免疫病理过程，研究采用ELISA和蛋白质印迹法进行验证。
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建议通过PubMed、Google Scholar等平台以关键词“TPM2 antibody”或“anti-TPM2”检索更多实际文献。
**Background of TPM2 Antibodies**
TPM2 (Tropomyosin 2) is a member of the tropomyosin family, a group of actin-binding proteins critical for regulating muscle contraction and stabilizing cytoskeletal structures. Encoded by the *TPM2* gene, this protein exists as multiple isoforms due to alternative splicing, allowing tissue-specific functions. TPM2 isoforms are integral to skeletal and smooth muscle function, where they modulate the interaction between actin filaments and myosin during contraction. In non-muscle cells, they contribute to cell shape, motility, and intracellular transport by organizing actin networks.
TPM2 antibodies are tools used to detect and study the expression, localization, and functional roles of TPM2 in biological systems. These antibodies are essential in research applications like immunohistochemistry (IHC), Western blotting (WB), and immunofluorescence (IF), enabling insights into TPM2’s involvement in physiological and pathological processes. Dysregulation of TPM2 has been linked to congenital muscle disorders (e.g., nemaline myopathy, distal arthrogryposis) and cancer, where altered cytoskeletal dynamics influence tumor progression.
Antibodies targeting TPM2 must account for isoform specificity due to structural variations. Their development and validation are crucial for ensuring accurate experimental outcomes, aiding both mechanistic studies and potential diagnostic applications. Research using TPM2 antibodies continues to uncover its role in cellular mechanics and disease pathways, highlighting its importance as a biomarker and therapeutic target.
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