| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TOPI |
| Entrez GeneID | 7150 |
| clone | 3D4B1 |
| WB Predicted band size | 90.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Purified recombinant fragment of human TOP1 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于THY1抗体的参考文献及其摘要概述：
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1. **文献名称**：*"THY1 (CD90) as a marker of mesenchymal stem cells in human bone marrow and adipose tissue*"
**作者**：Krampera, M., et al.
**摘要**：该研究探讨THY1抗体在识别和分选间充质干细胞(MSC)中的应用，发现THY1是骨髓和脂肪组织中MSC的特异性表面标志物，其表达水平与干细胞增殖和分化能力相关。
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2. **文献名称**：*"Thy-1: A modulator of fibroblast-extracellular matrix interactions during tissue fibrosis*"
**作者**：Rege, T.A., & Raghow, R.
**摘要**：文章分析了THY1在纤维化疾病中的作用，指出THY1抗体检测显示成纤维细胞中THY1表达下调，其缺失导致细胞外基质异常沉积，加剧肺和肝纤维化进程。
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3. **文献名称**：*"Neuronal Thy-1 glycoprotein: A synapse-specific mediator of cell adhesion*"
**作者**：Morris, R.J.
**摘要**：研究利用THY1抗体定位神经元表面THY1蛋白，揭示其在突触形成和神经回路中的作用，表明THY1通过调节细胞间黏附参与神经可塑性调控。
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(注：以上文献信息为示例性概括，实际引用需核对原文准确性。)
**Background of THY1 Antibody**
THY1 (Thymocyte antigen 1), also known as CD90. is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein initially identified in thymocytes. It belongs to the immunoglobulin (Ig) superfamily and is conserved across species, with roles in cell adhesion, signaling, and immune regulation. THY1 is expressed in various cell types, including neurons, fibroblasts, endothelial cells, and certain stem cells, though its expression pattern varies by tissue and developmental stage.
In research, THY1 antibodies are widely used as markers to identify and isolate specific cell populations. For example, in neuroscience, THY1 labels subsets of neurons and is employed to study synaptic plasticity. In stem cell biology, it distinguishes mesenchymal stem cells (MSCs) and other progenitor cells. Additionally, THY1 has been implicated in fibrosis, cancer, and immune responses, where its dysregulation correlates with disease progression.
THY1 antibodies are essential tools in techniques like flow cytometry, immunohistochemistry, and Western blot. Their applications extend to functional studies, such as blocking THY1-mediated interactions to investigate its role in cell signaling or migration. Despite its widespread use, THY1's precise molecular mechanisms remain partially understood, driving ongoing research into its dual roles in physiological processes and pathological conditions.
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