| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | EDG7; GPCR; LPA3; Edg-7; LP-A3; HOFNH30; RP4-678I3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human LPAR3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LPAR3抗体的3篇参考文献示例(注：文献信息为模拟示例，实际引用需核实原文)：
1. **文献名称**: "Lysophosphatidic Acid Receptor 3 Promotes Tumor Cell Migration and Invasion in Ovarian Cancer"
**作者**: Smith A, et al.
**摘要**: 研究通过免疫组化和小鼠模型，利用LPAR3特异性抗体证实其在卵巢癌细胞中的高表达，并揭示其通过激活Rho信号通路促进肿瘤侵袭的机制。
2. **文献名称**: "Targeting LPAR3 in Pulmonary Fibrosis: A Novel Therapeutic Approach"
**作者**: Tanaka K, et al.
**摘要**: 使用LPAR3抗体进行Western blot和免疫荧光实验，发现肺纤维化患者组织中LPAR3表达显著上调，抑制其活性可减轻纤维化进程。
3. **文献名称**: "Monoclonal Antibody Development for LPAR3 and Its Functional Characterization"
**作者**: Lee JH, et al.
**摘要**: 报道一种新型抗人LPAR3单克隆抗体的开发，通过流式细胞术和ELISA验证其高特异性，并应用于检测乳腺癌细胞表面LPAR3的分布。
(提示：实际文献需通过PubMed或Google Scholar以关键词“LPAR3 antibody”、“LPA receptor 3”结合研究领域进一步检索。)
The lysophosphatidic acid receptor 3 (LPAR3), also known as LPA₃, is a G protein-coupled receptor (GPCR) that binds lysophosphatidic acid (LPA), a bioactive phospholipid involved in diverse cellular processes. LPAR3 is encoded by the LPAR3 gene and primarily signals through Gq/11 proteins, activating pathways like phospholipase C (PLC), which regulates calcium mobilization and protein kinase C (PKC). It plays roles in physiological functions such as cell proliferation, migration, and survival, as well as pathological conditions including cancer progression, fibrosis, and inflammation. LPAR3 is expressed in various tissues, notably the reproductive system, immune cells, and certain tumors.
LPAR3 antibodies are essential tools for studying the receptor's expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to detect LPAR3 in biological samples. These antibodies aid in exploring LPAR3's involvement in diseases, such as its overexpression in ovarian or breast cancers, which correlates with metastasis and poor prognosis. Additionally, LPAR3-targeting antibodies have potential therapeutic applications, including blocking LPA-mediated signaling in cancer or fibrotic disorders. Validation of antibody specificity is critical, often achieved via knockout controls or competitive binding assays. Research on LPAR3 continues to uncover its pathophysiological roles, driving demand for reliable antibodies in both basic and clinical studies.
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