关键信息
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基因名
GBP1
- 应用
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别名
IBP1; B-cell signal transduction molecule alpha 4; CD79a-binding protein 1; Protein phosphatase 2/4/6 regulatory subunit; Renal carcinoma antigen NY-REN-16
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P78318
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表达区间
Met1~Gly339
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分子量
70kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GBP1 (Guanylate Binding Protein 1) is an important member of the guanylate-binding protein family, which plays a crucial role in the immune response and the host's defense against bacterial and viral infections. Research has highlighted GBP1's involvement in various cellular processes, including the regulation of inflammatory responses and the modulation of autophagy. Upon activation by interferons, GBP1 can localize to stress granules and microbial vacuoles, where it participates in pathogen elimination and the regulation of immune signaling pathways. Additionally, GBP1 has been implicated in several diseases, including cancer, where its expression levels can influence tumor progression and metastasis. Understanding the structure and function of GBP1 through protein reconstitution studies can provide insights into its mechanism of action and its potential as a therapeutic target. Recent advancements in molecular biology techniques have facilitated detailed analyses of GBP1's interactions with other proteins and its role in cellular signaling networks. This research is not only vital for comprehending GBP1's biological functions but also has significant implications for developing innovative strategies to enhance immune responses in infectious diseases and cancer therapy. The exploration of GBP1 as a biomarker or a target for drug design could pave the way for novel therapeutic interventions aimed at modulating the immune system effectively.
