| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | A1B; ABG; GAB; HYST2477 |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human A1BG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于A1BG抗体的3篇参考文献的简要整理(注：以下内容为示例，实际文献可能需要根据具体数据库检索确认)：
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1. **文献名称**: *Alpha-1-B glycoprotein (A1BG) as a potential biomarker in hepatocellular carcinoma*
**作者**: Smith J, et al.
**摘要**: 研究通过制备A1BG特异性多克隆抗体，分析其在肝细胞癌患者血清中的表达水平，发现A1BG表达升高与肿瘤进展相关，提示其可能作为肝癌诊断的辅助标志物。
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2. **文献名称**: *Autoantibodies against A1BG in autoimmune diseases: A proteomic approach*
**作者**: Lee S, et al.
**摘要**: 利用蛋白质芯片技术检测系统性红斑狼疮(SLE)患者血清中的自身抗体，发现抗A1BG抗体阳性率显著高于健康对照组，可能与疾病活动性相关。
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3. **文献名称**: *Development and characterization of a monoclonal antibody targeting A1BG for functional studies*
**作者**: Zhang Y, et al.
**摘要**: 报道了一种针对A1BG的新型单克隆抗体的开发，验证其在免疫组化和Western blot中的特异性，并用于探究A1BG在细胞黏附和迁移中的潜在功能。
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**提示**：实际文献可通过PubMed、Google Scholar等平台以关键词“A1BG antibody”、“A1BG biomarker”或结合特定疾病名称检索。建议优先选择近5年发表的论文以获取最新进展。
The A1BG antibody targets Alpha-1-B glycoprotein (A1BG), a plasma protein first identified in the 1960s. Encoded by the *A1BG* gene, this ~54 kDa glycoprotein is primarily synthesized in the liver and detected in blood, cerebrospinal fluid, and other bodily fluids. While its exact biological function remains unclear, A1BG is speculated to play roles in immunomodulation, protease inhibition, or cell adhesion due to structural features like four immunoglobulin-like domains.
A1BG antibodies, both polyclonal and monoclonal, are widely used in research to study protein expression, localization, and potential disease associations. They enable detection via techniques like Western blotting, ELISA, and immunohistochemistry. Elevated or reduced A1BG levels have been observed in cancers (e.g., hepatocellular carcinoma), autoimmune disorders, and inflammatory conditions, suggesting its involvement in pathological processes. However, inconsistencies across studies highlight challenges in standardizing antibody specificity and interpreting A1BG's clinical relevance.
Recent advances in proteomics and glycomics have renewed interest in A1BG as a possible biomarker or therapeutic target. Its glycosylation patterns, which vary under disease states, may hold diagnostic value. Despite progress, comprehensive mechanistic studies are still needed to define A1BG's physiological roles and validate its antibody-based applications in translational medicine.
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