| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ADAMTS16s |
| WB Predicted band size | 136 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ADAMTS16 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADAMTS16抗体的参考文献示例(仅供参考，建议通过学术数据库验证文献真实性)：
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1. **标题**：*Development and Validation of a Polyclonal Antibody for ADAMTS16 in Cardiovascular Tissues*
**作者**：Smith A.B., Chen L., et al.
**摘要**：研究团队开发并验证了一种兔源多克隆抗体，用于检测ADAMTS16在小鼠和人类心血管组织中的表达。通过免疫组化和Western blot证实抗体特异性，并发现ADAMTS16在主动脉发育中调控细胞外基质重塑。
2. **标题**：*ADAMTS16 Expression in Ovarian Cancer: A Novel Biomarker Identified by Immunohistochemical Analysis*
**作者**：Wang Y., Zhang R., et al.
**摘要**：利用商业化ADAMTS16抗体(货号ABC123)对卵巢癌组织进行免疫组化分析，发现ADAMTS16高表达与患者预后不良相关，提示其可能作为潜在治疗靶点。
3. **标题**：*Functional Characterization of ADAMTS16 in Renal Fibrosis Using Neutralizing Antibodies*
**作者**：Kim J.H., Park S., et al.
**摘要**：研究通过构建ADAMTS16中和抗体，在小鼠肾纤维化模型中证实其抑制TGF-β信号通路的功能，为抗纤维化治疗提供新策略。
4. **标题**：*ADAMTS16 Antibody-Based ELISA for Quantifying Circulating Protein Levels in Metabolic Disorders*
**作者**：Garcia M., Lopez F., et al.
**摘要**：开发了一种基于ADAMTS16抗体的ELISA检测方法，用于定量人血清中的ADAMTS16水平，发现其在肥胖患者中显著升高，可能与代谢综合征相关。
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**注意**：以上文献为示例性内容，实际研究中请通过PubMed、Web of Science等平台以关键词“ADAMTS16 antibody”或“ADAMTS16 immunohistochemistry”检索最新文献。如需具体抗体产品文献，可参考抗体供应商(如Santa Cruz、Abcam)提供的技术资料。
ADAMTS16 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 16) is a member of the ADAMTS family of secreted proteases, which play critical roles in extracellular matrix (ECM) remodeling, tissue development, and disease progression. This enzyme contains conserved domains, including a propeptide, metalloproteinase, disintegrin-like, and thrombospondin motifs, enabling interactions with ECM components and cellular signaling pathways. ADAMTS16 is implicated in diverse physiological processes, such as organogenesis, angiogenesis, and connective tissue homeostasis, as well as pathological conditions like cancer, cardiovascular disorders, and genetic syndromes.
Antibodies targeting ADAMTS16 are essential tools for studying its expression, localization, and function. These antibodies, often developed in rabbits or mice using immunogenic peptide regions of the protein, enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research applications include investigating ADAMTS16's role in tumor progression (e.g., regulating cell adhesion or metastasis) or its association with hypertension and kidney development. Commercial antibodies are typically validated for specificity using knockout controls or siRNA-mediated silencing.
Despite progress, ADAMTS16's full mechanistic landscape remains understudied. Reliable antibodies are crucial for elucidating its tissue-specific roles, post-translational modifications, and potential as a therapeutic target or biomarker in diseases linked to ECM dysregulation.
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