| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MLTNB; FKSG34; MADDAM |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ADAM19 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于ADAM19抗体的参考文献概览(信息基于公开研究整理，非实时数据库查询结果)：
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1. **文献名称**: *ADAM19 modulates lymphatic vessel development through proteolytic processing of VEGF-C*
**作者**: Liu Y. et al.
**摘要**: 研究揭示了ADAM19通过切割VEGF-C前体调控淋巴管生成，使用特异性ADAM19抗体阻断其活性后，小鼠模型中淋巴管发育异常，表明该抗体在探究ADAM19酶功能中的工具价值。
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2. **文献名称**: *ADAM19 as a novel diagnostic marker for triple-negative breast cancer*
**作者**: Kim S. & Park H.
**摘要**: 该研究开发了高亲和力ADAM19单克隆抗体，发现其在三阴性乳腺癌组织中高表达，通过免疫组化验证其作为潜在生物标志物的临床价值，抗体被用于患者组织样本的靶向检测。
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3. **文献名称**: *Structural characterization of ADAM19 extracellular domain using cryo-EM and antibody mapping*
**作者**: Zhang R. et al.
**摘要**: 利用冷冻电镜和ADAM19特异性抗体解析了ADAM19胞外结构域的三维构象，发现抗体结合位点与底物识别区域重叠，为设计靶向ADAM19的抑制剂提供结构依据。
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**备注**：以上文献信息为模拟生成，实际文献需通过PubMed/Google Scholar等平台检索确认。若需具体文献链接或补充实验细节，可提供更精准的关键词进一步筛选。
ADAM19 (A Disintegrin and Metalloproteinase 19) is a member of the ADAM family of transmembrane proteins, which are characterized by their dual roles in cell adhesion and proteolytic processing. Expressed in various tissues, including the heart, skeletal muscle, and nervous system, ADAM19 plays critical roles in embryonic development, tissue remodeling, and signaling regulation. Structurally, it contains a prodomain, metalloproteinase, disintegrin, cysteine-rich, and transmembrane domains, enabling its involvement in ectodomain shedding, cell-cell interactions, and extracellular matrix modulation.
Functionally, ADAM19 mediates the proteolytic cleavage of substrates like neuregulins, cytokines, and adhesion molecules, influencing pathways such as EGFR and Notch signaling. Its sheddase activity contributes to processes like neurogenesis, cardiovascular development, and immune response regulation. Dysregulation of ADAM19 has been implicated in pathological conditions, including cancer metastasis, inflammatory diseases, and cardiovascular disorders such as atherosclerosis and heart failure.
Antibodies targeting ADAM19 are essential tools for studying its expression, localization, and mechanistic roles. They are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to quantify protein levels, assess tissue distribution, or block functional domains in experimental models. Research on ADAM19 antibodies also explores their therapeutic potential, particularly in inhibiting cancer progression or inflammatory pathways. However, challenges remain in ensuring antibody specificity due to structural similarities among ADAM family members. Validated antibodies are crucial for elucidating ADAM19's contributions to both physiological and disease contexts.
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