| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | AGP4; ANG4; ANG-3 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ANGPT4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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经核查，"ANGPT4"可能为笔误，正确名称应为"ANGPTL4"(血管生成素样蛋白4)。以下是关于ANGPTL4抗体的参考文献示例(注：文献为虚拟示例，实际研究中请核实)：
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1. **文献名称**: *ANGPTL4 modulates vascular endothelial permeability through integrin-mediated signaling*
**作者**: Smith J, et al.
**摘要**: 本研究利用抗ANGPTL4单克隆抗体，通过免疫组化和Western blot分析，揭示ANGPTL4通过整合素信号通路调控血管内皮通透性，为治疗血管渗漏相关疾病提供新靶点。
2. **文献名称**: *Development of a high-affinity antibody for detecting ANGPTL4 in human serum*
**作者**: Lee H, et al.
**摘要**: 报道一种新型抗ANGPTL4多克隆抗体的开发，验证其在ELISA和免疫荧光中的高特异性，成功应用于肥胖患者血清中ANGPTL4水平的定量分析。
3. **文献名称**: *ANGPTL4 promotes tumor metastasis via lipid metabolism reprogramming: insights from antibody-based inhibition studies*
**作者**: Zhang R, et al.
**摘要**: 通过抗ANGPTL4中和抗体阻断实验，证明ANGPTL4通过调节脂质代谢促进肿瘤转移，抗体干预显著抑制小鼠模型中肿瘤扩散。
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**注意**：实际研究中，建议通过PubMed或Web of Science检索最新文献，使用关键词"ANGPTL4 antibody"或结合具体研究领域(如代谢、癌症)筛选高影响力论文。若需具体文献，可提供更详细的研究方向以便精准推荐。
The angiopoietin-like protein 4 (ANGPTL4), occasionally misreferenced as ANGPT4. is a secretory glycoprotein involved in diverse physiological processes, including lipid metabolism, angiogenesis, and tissue repair. Structurally, it shares homology with angiopoietins but lacks receptor-binding specificity for Tie receptors. ANGPTL4 is primarily regulated by hypoxia, fasting, and inflammatory signals, functioning as a metabolic regulator by inhibiting lipoprotein lipase (LPL) to modulate triglyceride clearance. Its dual role in vascular biology—promoting or inhibiting angiogenesis depending on proteolytic processing and tissue context—has sparked interest in cancer research, as it influences tumor progression and metastasis via vascular remodeling and cell migration.
Antibodies targeting ANGPTL4 have been developed to study its molecular mechanisms and therapeutic potential. These tools enable detection of ANGPTL4 isoforms in immunoassays, histopathology, and functional studies. In metabolic disorders, anti-ANGPTL4 antibodies are explored for neutralizing its LPL-inhibitory activity to ameliorate hypertriglyceridemia. Conversely, in oncology, blocking antibodies may suppress pro-metastatic signaling. Challenges include specificity due to post-translational modifications and context-dependent functions. Current research focuses on optimizing antibody affinity and isoform selectivity to advance diagnostic and therapeutic applications.
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