| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CSP2; RCN2; MCIP2; ZAKI4; ZAKI-4; DSCR1L1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human RCAN2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于RCAN2抗体的3篇参考文献示例(内容为模拟，非真实文献)：
---
1. **文献名称**：*RCAN2 Expression in Alzheimer’s Disease: A Role in Neurodegeneration*
**作者**：Smith A, et al.
**摘要**：研究通过免疫印迹(Western blot)和免疫组化(IHC)分析RCAN2蛋白在阿尔茨海默病患者脑组织中的表达。结果表明，RCAN2在病变区域的神经元中显著上调，提示其可能通过钙信号通路参与神经退行性过程。实验中使用了特异性RCAN2抗体验证蛋白表达水平。
---
2. **文献名称**：*RCAN2 as a Tumor Suppressor in Colorectal Cancer*
**作者**：Li X, et al.
**摘要**：研究探讨RCAN2在结直肠癌中的抑制作用，通过免疫荧光和Western blot技术检测RCAN2在癌细胞系中的定位及表达。实验发现RCAN2低表达与肿瘤侵袭性相关，并利用RCAN2抗体确认了其在细胞核和胞质中的分布差异。
---
3. **文献名称**：*Role of RCAN2 in Cardiac Hypertrophy*
**作者**：Wang Y, et al.
**摘要**：该研究通过免疫沉淀(IP)和免疫印迹技术，结合RCAN2特异性抗体，揭示了RCAN2在心脏肥大模型中的动态调控。结果显示，RCAN2通过与钙调磷酸酶相互作用抑制病理性心肌肥厚，为潜在治疗靶点提供了依据。
---
如需真实文献，建议通过PubMed或Google Scholar搜索关键词“RCAN2 antibody”、“RCAN2 immunodetection”获取具体研究。
The RCAN2 (Regulator of Calcineurin 2) antibody is a research tool designed to detect and study the RCAN2 protein, a member of the RCAN family involved in regulating intracellular signaling pathways. RCAN2. encoded by the RCAN2 gene located on human chromosome 6 (6p21.1), acts as a modulator of calcineurin, a calcium-dependent phosphatase critical for immune response, cardiac hypertrophy, and neuronal development. By binding to calcineurin, RCAN2 inhibits its activity, thereby influencing downstream targets like NFAT (Nuclear Factor of Activated T-cells) transcription factors. Dysregulation of RCAN2 has been implicated in pathological conditions, including Down syndrome, Alzheimer’s disease, and cancer, where altered calcineurin signaling contributes to disease progression.
The RCAN2 antibody is widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to evaluate protein expression, localization, and post-translational modifications in various tissues and cell lines. Researchers employ it to explore RCAN2’s role in cellular processes like apoptosis, stress response, and mitochondrial function. Commercially available RCAN2 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes within the protein’s conserved regions. Validation often includes knockout controls and cross-reactivity assessments to ensure specificity. Its application extends to both basic research and clinical studies, particularly in understanding the molecular mechanisms of neurodevelopmental disorders and malignancies linked to RCAN2 dysregulation.
×
