| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | SuPr-2 |
| WB Predicted band size | 73 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SENP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SENP1抗体的3篇参考文献(信息基于公开研究整理，非真实文献，仅供示例参考)：
1. **文献名称**：*SENP1 regulates HIF-1α stability through deSUMOylation in hypoxic conditions*
**作者**：Cheng et al.
**摘要**：研究揭示了SENP1通过去SUMO化修饰调控HIF-1α在缺氧环境中的稳定性，使用SENP1抗体进行免疫印迹和免疫共沉淀实验，证实其在肿瘤血管生成中的关键作用。
2. **文献名称**：*SENP1-mediated deSUMOylation of STAT3 promotes cardiac hypertrophy*
**作者**：Wang et al.
**摘要**：文章通过SENP1抗体检测心脏组织中SENP1的表达水平，发现其通过调节STAT3的SUMO化状态参与心肌肥厚的病理过程，为心血管疾病治疗提供新靶点。
3. **文献名称**：*Development and validation of a specific SENP1 antibody for cancer biomarker studies*
**作者**：Liu et al.
**摘要**：该研究报道了一种高特异性SENP1多克隆抗体的开发与验证，通过免疫组化和Western blot证实其在多种癌症组织中高表达，提示SENP1作为潜在肿瘤标志物的价值。
如需具体文献，建议在PubMed或Web of Science中检索关键词"SENP1 antibody" + "application"或相关研究方向获取最新数据。
The sentrin-specific protease 1 (SENP1) antibody is a crucial tool for studying the regulation of SUMO (Small Ubiquitin-like Modifier) modification, a post-translational process involved in diverse cellular functions. SENP1. a member of the SENP protease family, catalyzes the cleavage of SUMO proteins from conjugated substrates, reversing SUMOylation and maintaining dynamic equilibrium in SUMO signaling. This enzyme preferentially processes SUMO-1 and SUMO-2/3 precursors and deconjugates SUMOylated proteins, influencing processes like transcriptional regulation, cell cycle progression, and DNA repair. Dysregulation of SENP1 has been linked to cancers, cardiovascular diseases, and neurological disorders, making it a research focus in disease mechanisms.
SENP1 antibodies are designed to detect endogenous SENP1 proteins in applications such as Western blotting, immunoprecipitation, and immunofluorescence. These antibodies typically target specific epitopes within SENP1's conserved catalytic domain or regulatory regions, enabling researchers to study its expression, localization, and interaction partners. Validation of SENP1 antibodies includes testing in knockout cell lines or tissues to confirm specificity. As SENP1 activity modulates critical pathways like HIF-1α and NF-κB signaling, its antibody serves as a vital reagent for investigating SUMOylation dynamics in both physiological and pathological contexts, offering insights into therapeutic targeting strategies.
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