| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | EVN; NBN; ENOVIN |
| WB Predicted band size | 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ARTN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ARTN(Artemin)抗体的3-4篇参考文献及其简要摘要：
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1. **文献名称**：Artemin promotes cisplatin resistance and neurogenic phenotype in breast cancer
**作者**：Shao L, et al.
**摘要**：该研究利用ARTN抗体分析其在乳腺癌细胞中的表达，发现ARTN通过激活EGFR/PI3K/Akt信号通路促进肿瘤对顺铂的耐药性，并与神经内分泌分化相关。
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2. **文献名称**：Artemin mediates tumorigenesis and metastasis via Wnt/β-catenin signaling in pancreatic cancer
**作者**：Banerjee A, et al.
**摘要**：研究通过ARTN抗体阻断实验证实，ARTN通过调控Wnt/β-catenin通路促进胰腺癌的生长和转移，提示其作为潜在治疗靶点。
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3. **文献名称**：Artemin-neutralizing antibody attenuates inflammatory pain in a mouse model
**作者**：Truong M, et al.
**摘要**：该研究使用ARTN特异性抗体在小鼠模型中抑制Artemin活性，发现其能显著减轻炎症性疼痛，表明ARTN在痛觉敏化中的关键作用。
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4. **文献名称**：Artemin is a survival factor for peripheral sensory neurons
**作者**：Baloh RH, et al.
**摘要**：早期研究通过ARTN抗体定位其表达，发现Artemin作为神经生长因子支持背根神经节神经元的存活，揭示其在周围神经系统发育中的功能。
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以上文献涵盖了ARTN抗体在癌症耐药性、神经痛机制及神经发育中的应用，均为相关领域的代表性研究。如需具体期刊信息或DOI，建议通过PubMed或ResearchGate进一步检索。
ARTN (Artemin), a member of the glial cell line-derived neurotrophic factor (GDNF) family, plays a critical role in neuronal development, survival, and plasticity. It binds to the GDNF family receptor α3 (GFRα3) and activates RET tyrosine kinase signaling, influencing processes like axon guidance, nociception, and tissue repair. Dysregulation of ARTN has been implicated in pathologies such as neuropathic pain, neurodegenerative disorders, and cancers, where it may promote tumor progression, metastasis, and chemoresistance.
ARTN antibodies are tools designed to target and modulate ARTN activity. These antibodies, including monoclonal and polyclonal variants, are used to study ARTN’s biological functions, block its interaction with GFRα3. or neutralize its downstream signaling. In research, they help elucidate ARTN’s role in neural circuit formation, pain sensitivity, and cancer biology. Therapeutically, ARTN-neutralizing antibodies are explored for conditions like chronic pain syndromes or cancers driven by ARTN overexpression. Conversely, agonistic antibodies may support neuroprotection in degenerative contexts. Challenges include optimizing specificity and delivery, particularly for crossing the blood-brain barrier in neurological applications. Current studies focus on validating ARTN as a biomarker and refining antibody-based strategies for clinical translation.
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