Rabbit Polyclonal KMT2C Antibody

The KMT2C antibody is a crucial tool for studying the lysine methyltransferase 2C (KMT2C), a histone-modifying enzyme within the KMT2/MLL family. KMT2C, also known as MLL3. plays a pivotal role in epigenetic regulation by catalyzing mono- and di-methylation of histone H3 at lysine 4 (H3K4me1/me2), primarily at enhancer regions, thereby modulating gene expression. It functions as part of the COMPASS-like complex, influencing cellular processes like differentiation, development, and tumor suppression. Dysregulation of KMT2C is linked to cancers (e.g., breast, lung, colorectal) and neurodevelopmental disorders, with mutations often correlating with poor prognosis. The KMT2C antibody enables detection and quantification of KMT2C protein levels in techniques such as Western blotting, immunoprecipitation, and immunofluorescence. Its specificity is validated using knockout controls to ensure accurate identification, given structural similarities among KMT2 family members. Research utilizing this antibody has advanced understanding of KMT2C’s role in chromatin remodeling, its interaction with tumor suppressors (e.g., p53), and potential therapeutic targeting in diseases driven by epigenetic dysfunction.