| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | AK6 |
| WB Predicted band size | 63 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human AK5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于AK5抗体的模拟参考文献示例(注：内容为虚构，仅供格式参考)：
1. **名称**：*AK5 Antibody Characterization and Its Role in Neuronal Energy Metabolism*
**作者**：Smith J, Lee R, et al.
**摘要**：本研究通过制备高特异性AK5多克隆抗体，揭示了AK5蛋白在小鼠海马体神经元中的高表达，并证实其在AMP-ADP转换中的关键作用，提示其可能与神经退行性疾病中的能量代谢异常相关。
2. **名称**：*AK5 Expression Profiling in Glioblastoma Using Novel Monoclonal Antibodies*
**作者**：Zhang L, Wang H, et al.
**摘要**：开发了一种新型AK5单克隆抗体，用于分析胶质母细胞瘤组织样本，发现AK5高表达与肿瘤细胞增殖和化疗耐药性显著相关，为潜在治疗靶点提供依据。
3. **名称**：*AK5 Knockout Mouse Model Reveals Immune Modulation Defects*
**作者**：Brown K, Garcia M, et al.
**摘要**：通过AK5抗体验证基因敲除小鼠模型，发现AK5缺失导致T细胞代谢重编程障碍，影响免疫应答效能，提示AK5在适应性免疫中的新功能。
4. **名称**：*Structural Insights into AK5 Isoforms via Phage Display-Derived Antibodies*
**作者**：Yamamoto T, Chen X, et al.
**摘要**：利用噬菌体展示技术筛选AK5异构体特异性抗体，结合冷冻电镜解析不同异构体的结构差异，为研究AK5在组织特异性代谢中的功能奠定基础。
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注：以上文献及内容均为模拟生成，实际研究中请通过PubMed、Web of Science等数据库检索真实文献。
The AK5 antibody is a tool used to study adenosine kinase 5 (AK5), a member of the adenosine kinase family involved in nucleotide metabolism. AK5 catalyzes the phosphorylation of adenosine to adenosine monophosphate (AMP), contributing to cellular energy homeostasis and nucleotide recycling. Unlike other adenosine kinase isoforms (e.g., AK1. AK2), AK5 is primarily localized in the mitochondria and exhibits tissue-specific expression, with higher levels detected in the brain, heart, and skeletal muscle. Its role in regulating adenosine levels links it to purinergic signaling, which influences processes like inflammation, neurotransmission, and apoptosis.
Research on AK5 has grown due to its potential implications in disease. Studies suggest AK5 dysregulation may correlate with metabolic disorders, neurodegenerative conditions, and cancer. For instance, altered AK5 expression has been observed in gliomas and breast cancers, hinting at its role in tumor metabolism. The AK5 antibody enables detection and quantification of AK5 protein in experimental models, supporting investigations into its biological functions. It is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to map AK5 distribution in tissues or assess its expression under pathological conditions. Recent work also explores AK5's interaction with mitochondrial pathways, emphasizing its importance in cellular stress responses. However, the full scope of AK5's physiological and pathological roles remains understudied, necessitating further research using targeted tools like the AK5 antibody.
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