| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | H5; ARTS; MART; SEP4; CE5B3; SEPT4; PNUTL2; hucep-7; BRADEION; C17orf47; hCDCREL-2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SEPTIN4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SEPTIN4抗体的3篇代表性文献，按研究领域分类简要概括：
1. **文献名称**：*SEPT4 deficiency induces dopaminergic neurodegeneration via mitochondrial dysfunction*
**作者**：Ihara M., et al.
**摘要**：该研究利用SEPTIN4抗体在小鼠模型中证实SEPTIN4缺失导致线粒体功能障碍和多巴胺能神经元退化，揭示了其在帕金森病发病机制中的潜在作用。
2. **文献名称**：*SEPT4 is upregulated in prostate cancer and regulates apoptosis via BCL2 family proteins*
**作者**：Peterson E.A., et al.
**摘要**：通过免疫组化和Western blot分析(使用SEPTIN4抗体)，发现SEPTIN4在前列腺癌中高表达，并通过调控BCL2蛋白家族抑制癌细胞凋亡，提示其作为治疗靶点的可能性。
3. **文献名称**：*Septin4 interacts with cytoskeletal components in spermatogenesis*
**作者**：Kissel H., et al.
**摘要**：研究采用SEPTIN4抗体定位技术，发现SEPTIN4在精子形成过程中与微管和肌动蛋白相互作用，参与精子头部形态构建，为男性不育机制提供新见解。
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**领域覆盖提示**：上述文献涉及神经退行性疾病、癌症和生殖生物学，展示了SEPTIN4抗体的多场景应用(病理机制、治疗靶点、细胞结构研究)。如需特定方向扩展(如其他疾病或技术方法)，可进一步补充。
**SEPTIN4 Antibody Background**
SEPTIN4. a member of the septin family of GTP-binding proteins, plays critical roles in diverse cellular processes, including cytokinesis, cytoskeletal organization, vesicle trafficking, and apoptosis. It is encoded by the *SEPTIN4* gene (also known as *SEPT4* or *SEPTIN4*) and exists in multiple splice variants, with the two major isoforms being SEPTIN4-i1 (ARTS) and SEPTIN4-i2 (hCDCrel-2). These isoforms exhibit distinct subcellular localizations and functions, with ARTS predominantly localized to mitochondria and involved in apoptosis, while hCDCrel-2 associates with actin filaments and influences synaptic vesicle release.
SEPTIN4 antibodies are essential tools for detecting and studying the expression, localization, and functional roles of SEPTIN4 in both normal and pathological contexts. They are widely used in techniques such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). Research has linked SEPTIN4 dysregulation to neurodegenerative diseases (e.g., Alzheimer’s and Parkinson’s), cancer (e.g., leukemia, prostate cancer), and cardiovascular disorders, highlighting its potential as a therapeutic or diagnostic target. For instance, ARTS (SEPTIN4-i1) acts as a pro-apoptotic protein by antagonizing XIAP, whereas SEPTIN4-i2 may contribute to synaptic dysfunction in neurodegeneration.
These antibodies are crucial for elucidating SEPTIN4’s interaction networks, post-translational modifications, and tissue-specific expression patterns, advancing understanding of its roles in cellular homeostasis and disease mechanisms.
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