| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | BAI2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ADGRB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADGRB2抗体的示例参考文献(注：以下内容为模拟生成，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *ADGRB2 regulates synaptic plasticity and dendritic spine formation in cortical neurons*
**作者**: Smith J, et al. (2020)
**摘要**: 本研究通过免疫荧光和Western blot技术，利用ADGRB2特异性抗体证实了该受体在神经元突触后膜的表达，并发现其通过调控RhoA信号通路影响树突棘形成和突触可塑性。
2. **文献名称**: *ADGRB2 as a biomarker in glioblastoma: Antibody-based detection and clinical correlations*
**作者**: Zhang L, et al. (2018)
**摘要**: 利用商业化ADGRB2抗体对胶质母细胞瘤组织进行免疫组化分析，发现ADGRB2高表达与患者预后不良相关，提示其可能作为肿瘤侵袭性的潜在标志物。
3. **文献名称**: *ADGRB2 deficiency disrupts blood-brain barrier integrity in a mouse model*
**作者**: Brown K, et al. (2021)
**摘要**: 通过ADGRB2抗体进行脑内皮细胞染色，发现ADGRB2缺失导致血管内皮钙黏蛋白分布异常，揭示了该受体在维持血脑屏障完整性中的关键作用。
4. **文献名称**: *Proteomic analysis of ADGRB2-interacting proteins using co-immunoprecipitation*
**作者**: Lee S, et al. (2019)
**摘要**: 使用ADGRB2抗体进行免疫共沉淀实验，鉴定出多个与ADGRB2相互作用的突触蛋白，包括神经连接蛋白NLGN1.提示其在神经细胞粘附中的功能网络。
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建议通过PubMed或Google Scholar以“ADGRB2 antibody”或“ADGRB2 function”为关键词检索最新文献，并优先选择近五年内发表的研究。
The ADGRB2 antibody is a research tool designed to detect ADGRB2 (Adhesion G Protein-Coupled Receptor B2), a member of the adhesion G protein-coupled receptor (GPCR) family. Also known as BAI2 (Brain-Specific Angiogenesis Inhibitor 2), ADGRB2 is characterized by a large extracellular N-terminal region involved in cell-cell or cell-matrix interactions and a seven-transmembrane domain typical of GPCRs. It plays roles in synaptic plasticity, neuronal migration, and vascular development, with high expression in the brain, particularly in the hippocampus and cerebral cortex. Dysregulation of ADGRB2 has been linked to neurological disorders, psychiatric conditions, and certain cancers.
ADGRB2 antibodies are typically produced in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions). They are validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence, often using knockout controls to confirm specificity. These antibodies enable researchers to study ADGRB2’s localization, expression patterns, and molecular interactions, providing insights into its physiological and pathological roles. Commercial antibodies may vary in clonality (monoclonal/polyclonal), species reactivity (human, mouse, rat), and conjugate formats (e.g., fluorescent tags), catering to diverse experimental needs in neuroscience, oncology, and developmental biology research.
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