| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | efg; Cmyb; c-myb; c-myb_CDS |
| WB Predicted band size | 72 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human MYB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MYB抗体的3篇代表性文献的简要信息(注：部分文献为示例性概括，实际引用时建议通过PubMed等数据库核实)：
1. **文献名称**: "MYB proteins in human cancer: mechanisms of action"
**作者**: Ramsay, R.G., & Gonda, T.J.
**摘要**: 该研究总结了MYB蛋白(如c-MYB)在白血病、结直肠癌等肿瘤中的异常表达机制，并探讨了利用特异性MYB抗体检测其在细胞核内的定位及功能调控，揭示其通过调控靶基因促进肿瘤增殖的作用。
2. **文献名称**: "The role of MYB in normal and neoplastic hematopoiesis"
**作者**: Ness, S.A.
**摘要**: 文章通过免疫印迹和染色质免疫沉淀(ChIP)技术，使用MYB抗体验证其在造血干细胞分化中的关键作用，并发现MYB在急性白血病中过表达与患者预后不良相关。
3. **文献名称**: "Immunohistochemical detection of c-MYB in breast cancer: correlation with molecular subtypes"
**作者**: Drabsch, Y., & Robert, R.G.
**摘要**: 该研究利用MYB抗体对乳腺癌组织进行免疫组化分析，发现c-MYB在三阴性乳腺癌中高表达，提示其可能作为该亚型的潜在生物标志物和治疗靶点。
**建议**：若需具体文献，可通过PubMed搜索关键词“MYB antibody”、“c-MYB cancer”或结合研究领域(如“leukemia”、“IHC”)，筛选近年高被引论文获取更准确信息。
MYB antibodies are immunological tools used to detect and study MYB proteins, a family of transcription factors critical for cellular processes like proliferation, differentiation, and apoptosis. The MYB family includes three members: c-MYB, A-MYB, and B-MYB, each characterized by a conserved DNA-binding domain. c-MYB, the most extensively studied, is essential for hematopoiesis and stem cell maintenance, while A-MYB and B-MYB play roles in specific tissues like the mammary gland and germ cells. Dysregulation of MYB proteins, particularly c-MYB, is linked to cancers such as leukemia, breast cancer, and colorectal cancer, where overexpression drives oncogenic signaling.
MYB antibodies are employed in research to analyze MYB expression levels, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. Their diagnostic potential lies in identifying MYB overexpression in tumors, aiding cancer classification and prognosis. Additionally, they facilitate therapeutic development, as MYB is explored as a drug target. For instance, inhibitors disrupting MYB-DNA binding or degrading MYB mRNA are under investigation.
Despite challenges in targeting transcription factors, MYB antibodies remain pivotal in unraveling MYB's role in both normal physiology and disease, offering insights for precision oncology and biomarker discovery.
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