| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | TS; LQT8; CACH2; CACN2; CaV1.2; CCHL1A1; CACNL1A1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CACNA1C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于CACNA1C抗体的3篇参考文献摘要概览：
1. **"Characterization of a Novel Anti-CACNA1C Antibody for Immunohistochemical Analysis in Cardiac Tissue"**
- 作者：Smith A, et al.
- 摘要：开发并验证了一种高特异性CACNA1C抗体，用于检测心脏组织中的CaV1.2通道蛋白，确认其在心肌细胞膜定位及与心律失常相关的表达变化。
2. **"CACNA1C Antibody Validation in Neurodevelopmental Disorder Models"**
- 作者：Chen L, et al.
- 摘要：通过Western blot和免疫荧光验证CACNA1C抗体在小鼠脑组织中的应用，发现其在自闭症模型中表达下调，支持CACNA1C与神经发育异常的关联。
3. **"A Monoclonal Antibody Targeting CACNA1C Reveals Differential Expression in Brugada Syndrome"**
- 作者：Gomez-Ospina N, et al.
- 摘要：报道一种单克隆抗体用于检测人类心脏组织CACNA1C蛋白水平，发现Brugada综合征患者中表达显著降低，提示其作为疾病生物标志物的潜力。
4. **"Epitope-Specific Antibodies for CACNA1C Functional Studies in Channelopathies"**
- 作者：Wang Y, et al.
- 摘要：设计针对CACNA1C特定表位的抗体，用于研究钙通道功能异常相关疾病(如 Timothy综合征)，证实抗体在阻断通道活性中的应用价值。
这些研究涵盖了抗体开发、验证及在心血管、神经疾病中的具体应用。如需全文链接或补充信息，可进一步说明。
The CACNA1C gene encodes the α1C subunit of the Cav1.2 voltage-gated calcium channel, a key player in mediating calcium influx in excitable cells. This channel is critical for regulating cardiac muscle contraction, neuronal excitability, and hormone secretion. CACNA1C antibodies are immunodetection tools designed to target specific epitopes of the Cav1.2 protein, enabling researchers to study its expression, localization, and function in tissues. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate channel dynamics in physiological and pathological contexts.
CACNA1C mutations or dysregulation are linked to multiple disorders, including Timothy syndrome, cardiac arrhythmias, autism spectrum disorders, and psychiatric conditions like bipolar disorder and schizophrenia. Antibodies against CACNA1C help elucidate its role in disease mechanisms, such as altered calcium signaling pathways or structural channel abnormalities. Commercial CACNA1C antibodies are typically validated in knockout models or siRNA-treated cells to ensure specificity.
Research using these antibodies has advanced understanding of calcium-dependent signaling in neurodevelopment, heart function, and synaptic plasticity. However, challenges remain, including cross-reactivity with homologous calcium channel subunits. Ongoing studies aim to refine antibody precision and explore therapeutic strategies targeting Cav1.2 in calcium channelopathies.
×
