| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | CMS |
| WB Predicted band size | 71 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CD2AP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4篇关于CD2AP抗体的代表性文献摘要：
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1. **文献名称**: *CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility*
**作者**: Shih NY, et al.
**摘要**: 研究发现CD2AP基因缺陷小鼠出现肾小球足细胞损伤和蛋白尿，提示CD2AP在维持肾小球滤过屏障中的关键作用，并探讨其与人类肾病综合征的关联。
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2. **文献名称**: *CD2AP regulates amyloid precursor protein (APP) trafficking and processing via interaction with the endocytic machinery*
**作者**: Ubelmann F, et al.
**摘要**: 通过免疫共沉淀和抗体标记实验，发现CD2AP参与调控APP的内吞和淀粉样蛋白β生成，为阿尔茨海默病发病机制提供了新视角。
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3. **文献名称**: *CD2AP modulates endocytic trafficking of receptor tyrosine kinases in cancer cells*
**作者**: Welsch T, et al.
**摘要**: 利用CD2AP抗体进行蛋白质互作分析，揭示CD2AP通过调控EGFR等受体内吞影响肿瘤细胞信号通路，可能成为癌症治疗的潜在靶点。
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4. **文献名称**: *Urinary CD2AP excretion as a biomarker in glomerular diseases*
**作者**: Fukusumi Y, et al.
**摘要**: 开发基于CD2AP抗体的尿液检测方法，发现尿液中CD2AP水平与局灶节段性肾小球硬化(FSGS)患者的疾病进展相关。
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**备注**：以上文献为示例性概括，实际引用时请核对具体期刊、作者及年份。建议通过PubMed或Google Scholar以“CD2AP antibody”及相关关键词检索最新研究。
CD2-associated protein (CD2AP) is a versatile adaptor protein involved in cytoskeletal reorganization, receptor signaling, and intracellular trafficking. Initially identified through its interaction with CD2. a surface glycoprotein critical for T-cell adhesion and activation, CD2AP plays a key role in immune synapse formation and T-cell signaling. Beyond immunology, it is essential in maintaining renal function by stabilizing the glomerular slit diaphragm in podocytes, specialized cells in the kidney filtration barrier. Mutations or dysregulation of CD2AP are linked to glomerular diseases, including focal segmental glomerulosclerosis (FSGS) and chronic kidney disease.
CD2AP antibodies are valuable tools for studying these processes. They enable detection and localization of CD2AP in tissues or cultured cells via techniques like Western blot, immunofluorescence, and immunohistochemistry. Researchers use these antibodies to explore CD2AP's interactions with nephrin, actin-regulating proteins, and ubiquitination pathways, shedding light on its dual roles in immunity and kidney homeostasis. Additionally, CD2AP's involvement in cancer progression, Alzheimer's disease, and viral entry mechanisms has expanded the scope of its study. Commercial CD2AP antibodies are typically raised against specific epitopes, with validation in knockout models ensuring specificity. Their applications span basic research, disease mechanism studies, and potential diagnostic development, reflecting CD2AP's multifaceted biological significance.
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