Rabbit Polyclonal CALCRL Antibody

The calcitonin receptor-like receptor (CALCRL), a class B G protein-coupled receptor (GPCR), plays a critical role in regulating cardiovascular, neurological, and metabolic processes. It functions as a core component of heterodimeric receptors when paired with receptor activity-modifying proteins (RAMPs). Depending on the RAMP subtype (1-3), CALCRL binds distinct ligands: calcitonin gene-related peptide (CGRP) with RAMP1. adrenomedullin (AM) with RAMP2/3. and amylin with RAMP3. These ligand-receptor complexes activate intracellular signaling pathways (e.g., cAMP, MAPK) to mediate vasodilation, inflammation modulation, and cellular proliferation. CALCRL antibodies are essential tools for studying receptor expression, localization, and signaling in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate CALCRL's roles in hypertension, heart failure, migraine (via CGRP signaling), and cancer progression. Species-specific reactivity (human, mouse, rat) and validation for selectivity against other GPCRs are critical considerations. Therapeutic targeting of CALCRL pathways, particularly in migraine (CGRP inhibitors) and cardiovascular diseases, underscores its clinical relevance.