| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CRF2; CRFR2; CRF-RB; HM-CRF |
| WB Predicted band size | 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CRHR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CRHR2抗体的3篇参考文献(示例为虚构内容，仅供参考格式)：
1. **文献名称**：*"Distribution and Function of Corticotropin-Releasing Hormone Receptor 2 in the Rodent Brain"*
**作者**：Smith A, et al.
**摘要**：通过免疫组化和Western blot分析，研究CRHR2抗体在小鼠脑区的特异性表达，揭示其在下丘脑、杏仁核等区域的分布，并探讨其在应激反应中的调控作用。
2. **文献名称**：*"CRHR2 Antibody Validation in Cardiovascular and Metabolic Studies"*
**作者**：Lee B, et al.
**摘要**：验证CRHR2抗体在心脏和血管组织中的特异性，证明其在CRHR2敲除模型中无交叉反应，并发现CRHR2激活可改善心肌缺血损伤。
3. **文献名称**：*"Role of CRHR2 in Anxiety-like Behavior: Insights from Antibody-based Receptor Localization"*
**作者**：Garcia C, et al.
**摘要**：利用CRHR2抗体研究其在边缘系统的表达模式，结合行为学实验，提出CRHR2通过抑制过度应激反应缓解焦虑症状。
4. **文献名称**：*"CRHR2 Signaling in Urocortin-mediated Stress Adaptation"*
**作者**：Tanaka K, et al.
**摘要**：通过抗体阻断实验，阐明CRHR2与配体Urocortin 2/3的相互作用机制，揭示其在应激适应中的保护性信号通路。
(注：以上文献为模拟示例，实际引用需查询PubMed或SciHub等学术数据库。)
Corticotropin-releasing hormone receptor 2 (CRHR2) is a G protein-coupled receptor that binds corticotropin-releasing hormone (CRH) and related peptides, playing a key role in modulating stress responses, anxiety, and energy homeostasis. It is widely expressed in the brain, cardiovascular system, and peripheral tissues, with distinct isoforms (CRHR2α, CRHR2β) arising from alternative splicing. CRHR2 activation influences diverse physiological processes, including appetite regulation, immune function, and cardiovascular adaptation, often counterbalancing the effects of its paralog, CRHR1. Dysregulation of CRHR2 signaling has been implicated in stress-related disorders, metabolic syndromes, and heart diseases.
CRHR2 antibodies are essential tools for investigating receptor localization, expression levels, and signaling mechanisms in both physiological and pathological contexts. These antibodies are designed to target specific epitopes within extracellular or intracellular domains, enabling applications such as immunohistochemistry, Western blotting, and flow cytometry. Species-specific variants (e.g., human, mouse, rat) are critical due to sequence divergence across models. Validation parameters, including knockout controls and peptide blocking assays, are crucial to ensure specificity, given the structural similarities between CRHR2 and other GPCRs. Recent studies using CRHR2 antibodies have clarified its neuroprotective roles and therapeutic potential in anxiety and heart failure, driving interest in drug development targeting this receptor.
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