| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CASPR3; CNTNAP3A; RP11-290L7.1; RP11-138L21.1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CNTNAP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇涉及CNTNAP3抗体的研究文献及其摘要概括(基于公开研究数据模拟，非真实文献)：
---
1. **文献名称**: *CNTNAP3 regulates cancer cell migration through β-catenin signaling*
**作者**: Smith J, et al.
**摘要**: 本研究利用CNTNAP3特异性抗体进行免疫印迹分析，发现CNTNAP3通过与β-catenin相互作用促进结直肠癌细胞迁移，抗体验证了其在肿瘤组织中的高表达与预后不良相关。
---
2. **文献名称**: *Neurexin family protein CNTNAP3 modulates synaptic plasticity in hippocampal neurons*
**作者**: Lee S, et al.
**摘要**: 通过免疫荧光和免疫沉淀技术，使用CNTNAP3抗体证实其在海马神经元突触中的定位，并揭示其缺失导致突触可塑性受损，提示其在神经发育中的潜在作用。
---
3. **文献名称**: *Proteomic profiling identifies CNTNAP3 as a novel biomarker in glioblastoma*
**作者**: Zhang Y, et al.
**摘要**: 采用CNTNAP3抗体进行组织微阵列分析，发现其在胶质母细胞瘤中特异性高表达，且与肿瘤侵袭性相关，提示其作为治疗靶点的可能性。
---
**注**: 以上文献为模拟示例，实际文献需通过PubMed或Google Scholar以关键词"CNTNAP3 antibody"+"gene function"检索。建议优先选择近5年、高影响因子期刊的研究。
The CNTNAP3 antibody targets the Contactin-associated protein-like 3 (CNTNAP3), a member of the neurexin superfamily involved in neuronal development and synaptic function. CNTNAP3. also known as CASPR3. is a transmembrane protein containing epidermal growth factor (EGF)-like domains and a cytoplasmic PDZ-binding motif, facilitating interactions with cell adhesion molecules and signaling pathways. It plays roles in cell-cell communication, axon guidance, and neural network formation, though its precise biological mechanisms remain under investigation.
Research on CNTNAP3 antibodies has expanded due to the protein's potential links to neurodevelopmental disorders and cancer. In neuroscience, these antibodies are used to study CNTNAP3 expression patterns in brain tissues, revealing its localization in specific neuronal populations and synapses. Aberrant CNTNAP3 expression has been implicated in glioblastoma and colorectal cancer, where it may influence tumor progression via cell adhesion and migration pathways. Additionally, CNTNAP3 autoantibodies have been explored in autoimmune conditions like systemic lupus erythematosus (SLE), suggesting a role in immune dysregulation.
Commercially available CNTNAP3 antibodies are primarily monoclonal or polyclonal reagents validated for techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Challenges include ensuring specificity due to structural similarities among neurexin family proteins. Ongoing studies aim to clarify CNTNAP3's physiological roles and its therapeutic or diagnostic potential in neurological and oncological contexts.
×
