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Rabbit Polyclonal COG1 Antibody

  • 中文名: COG1抗体
  • 别    名: LDLB; CDG2G
货号: IPDX11674
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/5000 Human,Mouse,Rat

产品详情

AliasesLDLB; CDG2G
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human COG1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是模拟的关于COG1抗体的参考文献示例(仅供参考,建议通过学术数据库检索真实文献):

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1. **标题**: *"COG1 Antibody Reveals Dynamic Localization of the Conserved Oligomeric Golgi Complex in Mammalian Cells"*

**作者**: Smith, J., et al.

**摘要**: 本研究利用COG1特异性抗体,通过免疫荧光和Western blot技术,揭示了COG1蛋白在高尔基体不同区室中的动态分布,并证明其在维持高尔基体结构完整性中的关键作用。

2. **标题**: *"Role of COG1 in Glycosylation Defects: Insights from COG1-Specific Antibody Staining"*

**作者**: Lee, H., & Kim, D.

**摘要**: 通过COG1抗体检测发现,COG1缺失导致细胞表面糖蛋白异常糖基化,表明COG1复合体在糖蛋白加工和运输中的必要性。

3. **标题**: *"COG1 Antibody-Based Screening Identifies Novel Mutations in Congenital Disorders of Glycosylation"*

**作者**: Garcia, M., et al.

**摘要**: 利用COG1抗体对患者细胞进行蛋白表达分析,发现了与先天性糖基化障碍(CDG)相关的新型COG1突变,为疾病机制研究提供了新方向。

4. **标题**: *"COG1 Knockdown and Antibody Validation in a Drosophila Model of Neurodegeneration"*

**作者**: Wang, Y., et al.

**摘要**: 在果蝇模型中,通过COG1抗体验证其蛋白表达下调与神经退行性变的相关性,提示COG1在神经元运输中的潜在作用。

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**注意**:以上文献为模拟示例,实际文献需通过PubMed、Google Scholar等平台检索关键词(如“COG1 antibody”、“COG1 function”)获取。真实研究可能集中在COG复合体的结构功能、疾病关联或细胞运输机制等领域。

背景信息

The COG1 antibody is a tool used to study the Conserved Oligomeric Golgi (COG) complex, a critical component in maintaining Golgi apparatus structure and function. The COG complex, composed of eight subunits (COG1-8), is divided into two subcomplexes: COG1-4 (subcomplex A) and COG5-8 (subcomplex B). COG1. a core subunit of subcomplex A, plays a pivotal role in vesicle tethering and retrograde trafficking within the Golgi, ensuring proper glycosylation, protein sorting, and organelle homeostasis. Dysregulation of COG1 is linked to congenital disorders of glycosylation (CDGs), such as CDG-II, characterized by impaired protein and lipid glycosylation. COG1 antibodies are widely employed in research to investigate Golgi dynamics, protein trafficking defects, and disease mechanisms. These antibodies enable detection of COG1 expression, localization, and interactions via techniques like Western blot, immunofluorescence, and immunoprecipitation. Studies using COG1 antibodies have revealed its involvement in neurological disorders and cancer, highlighting its broader biomedical relevance. By elucidating COG1's molecular interactions, researchers aim to uncover therapeutic targets for Golgi-related pathologies.

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