Rabbit Polyclonal MAF Antibody

MAF (musculoaponeurotic fibrosarcoma) antibodies are essential tools in studying the MAF family of transcription factors, which play critical roles in cellular differentiation, proliferation, and apoptosis. The MAF family includes proteins like c-MAF, MAFA, MAFB, and MAFG, characterized by a conserved basic leucine zipper (bZIP) domain for DNA binding and dimerization. These proteins regulate gene expression by binding to MARE (MAF recognition element) sequences, often in combination with other transcription factors. Dysregulation of MAF proteins is linked to diseases, particularly cancer. For example, c-MAF overexpression is associated with multiple myeloma progression and poor prognosis, while MAFB is vital in immune cell development. MAF antibodies are widely used in research to detect MAF protein expression and localization via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They help elucidate MAF’s role in oncogenesis, immune regulation, and metabolic pathways, aiding in biomarker discovery and therapeutic targeting. Recent studies also explore MAF proteins in autoimmune diseases and neurodegenerative conditions, expanding their clinical relevance. MAF antibodies thus serve as pivotal reagents in both basic research and translational applications, bridging molecular mechanisms to potential diagnostic or therapeutic strategies.