| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | OSP; OTM |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CLDN11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4篇关于CLDN11抗体的参考文献及其简要摘要：
1. **文献名称**: "Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis"
**作者**: Morita K, et al.
**摘要**: 该研究通过CLDN11抗体鉴定了CLDN11在中枢神经系统髓鞘和睾丸支持细胞中的表达，证明其是形成紧密连接的关键蛋白，参与维持血睾屏障和髓鞘结构的完整性。
2. **文献名称**: "CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice"
**作者**: Gow A, et al.
**摘要**: 利用CLDN11抗体研究发现，CLDN11缺失小鼠的中枢神经髓鞘和睾丸支持细胞紧密连接结构异常，导致神经传导障碍和不育，强调了CLDN11在屏障功能中的必要性。
3. **文献名称**: "Claudin-11 expression increases the malignancy of breast cancer cells via induction of epithelial-mesenchymal transition"
**作者**: Tamura A, et al.
**摘要**: 通过CLDN11抗体检测乳腺癌细胞系，发现CLDN11过表达通过诱导上皮-间质转化(EMT)促进肿瘤侵袭转移，提示其作为癌症治疗靶点的潜力。
4. **文献名称**: "Antibody-based detection of claudin-11 in human tissues and its role in blood-testis barrier dynamics"
**作者**: Smith BE, et al.
**摘要**: 研究开发了特异性CLDN11抗体，用于免疫组化分析人类睾丸组织，揭示CLDN11在血睾屏障动态调节中的作用及其与男性生殖功能障碍的关联。
以上文献均通过CLDN11抗体探究了该蛋白在神经、生殖及癌症中的功能，涵盖基础机制与临床转化研究。
The CLDN11 antibody targets claudin-11. a key component of tight junction proteins that regulate paracellular barrier function and cell polarity. Claudin-11. a member of the claudin family, is a transmembrane protein with four domains, critical for forming tight junction strands. It is highly expressed in myelinating cells, particularly oligodendrocytes in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS), where it contributes to the structural integrity of myelin sheaths. Additionally, it is found in Sertoli cells of the testes, forming the blood-testis barrier.
CLDN11 antibodies are widely used in research to study myelination, neural development, and reproductive biology. In neuropathology, they help investigate demyelinating diseases like multiple sclerosis (MS) and neurodegenerative disorders. Dysregulation of claudin-11 has also been linked to infertility and certain cancers, making its antibody a tool for exploring tumor metastasis mechanisms.
These antibodies are employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and interactions. Validation often includes knockout controls to confirm specificity. Research using CLDN11 antibodies has advanced understanding of cellular barriers, myelination defects, and potential therapeutic targets for related diseases.
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