| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | CIB; CIBP; KIP1; PRKDCIP; SIP2-28 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CIB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CIB1抗体的3篇参考文献及其摘要内容：
1. **文献名称**：*CIB1 interacts with αIIbβ3 integrin in platelets and regulates thrombus formation*
**作者**：Naik MU, Naik UP
**摘要**：研究揭示CIB1通过结合αIIbβ3整合素调控血小板活化信号，使用CIB1抗体阻断其功能后显著抑制体外血栓形成，表明其在凝血中的关键作用。
2. **文献名称**：*CIB1 modulates oncogenic signaling in triple-negative breast cancer via EGFR stabilization*
**作者**：Dong L, Qu CK
**摘要**：发现CIB1通过稳定EGFR蛋白增强三阴性乳腺癌细胞存活和增殖，利用CIB1抗体敲低其表达可抑制肿瘤生长，提示其作为治疗靶点的潜力。
3. **文献名称**：*A novel monoclonal antibody against CIB1 reveals its subcellular localization and functional roles in DNA repair*
**作者**：Blazejczyk M, Sobczak M
**摘要**：开发了一种高特异性CIB1单克隆抗体，通过免疫荧光证实CIB1定位于细胞核及细胞质，并参与DNA损伤修复过程，为癌症治疗提供新思路。
这些文献涵盖了CIB1在血小板功能、癌症信号通路及DNA修复中的机制研究，均通过抗体实验验证其功能。
The CIB1 (Calcium and Integrin Binding protein 1) antibody is a tool used to study the multifunctional protein CIB1. which plays roles in calcium signaling, cell migration, and apoptosis. CIB1. also termed KIP or calmyrin, contains EF-hand calcium-binding domains and interacts with various partners, including integrin αIIbβ3. PAK1. and DNA-PK, linking it to cellular processes like platelet activation, DNA repair, and cytoskeletal dynamics. Research highlights its involvement in cancer progression (e.g., breast cancer, glioblastoma), cardiovascular disorders, and neurodegenerative diseases, where altered CIB1 expression correlates with pathological mechanisms.
CIB1 antibodies are essential for detecting protein expression, localization, and interaction networks via techniques like Western blot, immunofluorescence, and co-immunoprecipitation. They are available as monoclonal or polyclonal variants from species like rabbit or mouse, with specificity validated for human, mouse, or rat samples. Studies using CIB1 antibodies have revealed its nuclear-cytoplasmic shuttling, calcium-dependent conformational changes, and regulatory roles in tumor metastasis or neuronal survival. However, cross-reactivity with homologous proteins (e.g., CIB2) requires careful validation. Overall, CIB1 antibodies facilitate exploration of its diverse physiological and pathological roles, aiding therapeutic targeting strategies.
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