| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216 |
| WB Predicted band size | 79 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TSPYL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TSPYL2抗体的3篇代表性文献示例(注：内容为模拟概括，实际文献需通过学术数据库查询)：
1. **文献名称**：*TSPYL2 is a novel epigenetically silenced tumor suppressor in ovarian cancer*
**作者**：Smith A, et al.
**摘要**：研究通过免疫组化发现TSPYL2蛋白在卵巢癌组织中表达显著降低，且启动子高甲基化是其沉默机制。体外实验表明TSPYL2过表达抑制癌细胞增殖并诱导凋亡，提示其作为抑癌基因的潜力。
2. **文献名称**：*TSPYL2 regulates cell cycle progression via interaction with CDK inhibitors in lung adenocarcinoma*
**作者**：Zhang L, et al.
**摘要**：该研究利用TSPYL2抗体进行Western blot和免疫荧光实验，发现TSPYL2通过结合p21和p27调控CDK活性，抑制肺癌细胞G1/S期转化，其表达缺失与患者预后不良相关。
3. **文献名称**：*TSPYL2 expression correlates with neurodevelopmental disorders: Evidence from post-mortem brain analysis*
**作者**：Brown K, et al.
**摘要**：通过脑组织免疫染色发现，自闭症患者前额叶皮层中TSPYL2蛋白水平异常降低，可能与神经元分化缺陷相关，提示其在神经发育中的潜在作用。
如需具体文献，建议在PubMed或Google Scholar中以“TSPYL2 antibody”、“TSPYL2 function”为关键词检索。
**Background of TSPYL2 Antibody**
TSPYL2 (Testis-specific Y-encoded-like protein 2), also known as TSPY-like 2. is a member of the TSPY-family of proteins encoded by genes on the X and Y chromosomes. While its exact biological function remains under investigation, TSPYL2 is implicated in cell cycle regulation, chromatin remodeling, and tumor suppression. It shares homology with TSPY, a protein linked to germ cell proliferation, but unlike TSPY, TSPYL2 is expressed broadly in somatic tissues, including the brain, liver, and kidneys, rather than being restricted to reproductive organs.
Antibodies targeting TSPYL2 are essential tools for studying its expression, localization, and interaction partners. Research suggests TSPYL2 may act as a tumor suppressor by modulating pathways involving p53 and histone deacetylases (HDACs), influencing apoptosis and cell proliferation. Dysregulation of TSPYL2 has been observed in cancers such as hepatocellular carcinoma, ovarian cancer, and prostate cancer, where its loss or mutation correlates with disease progression.
In diagnostics, TSPYL2 antibodies are used in immunohistochemistry (IHC), Western blotting, and immunofluorescence to assess protein levels in tissue samples, aiding in cancer research and biomarker discovery. Additionally, studies explore its role in neurodevelopmental disorders, as TSPYL2 mutations are linked to intellectual disability and autism spectrum disorders.
Overall, TSPYL2 antibodies are pivotal in elucidating the protein’s dual roles in oncogenesis and neurological health, highlighting its potential as a therapeutic target or diagnostic marker.
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