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Rabbit Polyclonal IFT74 Antibody

  • 中文名： IFT74抗体
  • 别    名： CMG1; CCDC2; CMG-1
货号: IPDX11672
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/5000 Human,Mouse,Rat

产品详情

AliasesCMG1; CCDC2; CMG-1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human IFT74
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于IFT74抗体的3篇参考文献及其摘要概述：

1. **文献名称**: *"IFT74 is an essential component of the retrograde intraflagellar transport (IFT) machinery in ciliary signaling"*

**作者**: Wei Q, et al.

**摘要**: 本研究利用IFT74抗体证实了IFT74在纤毛逆向运输中的作用，通过免疫荧光定位显示其与IFT-B亚复合体的相互作用，缺失导致纤毛结构异常。

2. **文献名称**: *"Functional characterization of IFT74 mutations associated with ciliopathies using specific antibodies"*

**作者**: Smith JL, et al.

**摘要**: 通过Western blot和免疫共沉淀，作者发现IFT74抗体可识别患者突变体蛋白，揭示其与IFT81的结合缺陷，解释纤毛相关疾病的分子机制。

3. **文献名称**: *"Antibody-based analysis of IFT74 dynamics during ciliogenesis in mammalian cells"*

**作者**: Tanaka Y, et al.

**摘要**: 研究利用IFT74抗体实时追踪纤毛形成过程，发现IFT74在基体周围富集，敲低后导致纤毛长度缩短，证实其对运输复合体组装的关键作用。

注：上述文献信息为示例，实际文献需通过学术数据库检索确认。

背景信息

The IFT74 antibody is a research tool targeting the Intraflagellar Transport 74 (IFT74) protein, a critical component of the intraflagellar transport (IFT) complex B. IFT complexes are essential for the assembly, maintenance, and function of primary cilia, microtubule-based organelles acting as cellular signaling hubs. IFT74. along with IFT complex B subunits, facilitates anterograde transport of cargo from the ciliary base to the tip. Mutations in IFT genes are linked to ciliopathies, disorders affecting multiple organs, including the kidneys, retina, and nervous system. IFT74 antibodies are widely used in studies investigating ciliary biology, protein localization, and molecular mechanisms underlying ciliopathies. They enable detection of IFT74 expression via techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding in understanding its role in cilia-dependent signaling pathways (e.g., Hedgehog signaling) and disease pathogenesis. Such antibodies are often validated in model organisms (e.g., mice, zebrafish) and human cell lines, providing insights into developmental defects, cancer, or metabolic disorders associated with ciliary dysfunction. Researchers also utilize IFT74 antibodies to explore therapeutic strategies targeting cilia-related pathways.

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