Rabbit Polyclonal IFT74 Antibody

The IFT74 antibody is a research tool targeting the Intraflagellar Transport 74 (IFT74) protein, a critical component of the intraflagellar transport (IFT) complex B. IFT complexes are essential for the assembly, maintenance, and function of primary cilia, microtubule-based organelles acting as cellular signaling hubs. IFT74. along with IFT complex B subunits, facilitates anterograde transport of cargo from the ciliary base to the tip. Mutations in IFT genes are linked to ciliopathies, disorders affecting multiple organs, including the kidneys, retina, and nervous system. IFT74 antibodies are widely used in studies investigating ciliary biology, protein localization, and molecular mechanisms underlying ciliopathies. They enable detection of IFT74 expression via techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding in understanding its role in cilia-dependent signaling pathways (e.g., Hedgehog signaling) and disease pathogenesis. Such antibodies are often validated in model organisms (e.g., mice, zebrafish) and human cell lines, providing insights into developmental defects, cancer, or metabolic disorders associated with ciliary dysfunction. Researchers also utilize IFT74 antibodies to explore therapeutic strategies targeting cilia-related pathways.