Rabbit Polyclonal HID1 Antibody

The HID1 (HID Domain Containing 1) antibody is a research tool used to study the HID1 protein, which is implicated in regulating secretory pathways and neuroendocrine functions. First identified in studies of pituitary gland development, HID1 is a transmembrane protein localized to the trans-Golgi network (TGN) and secretory granules. It contains a conserved N-terminal HID domain and a C-terminal region critical for its role in protein trafficking, hormone secretion, and granule maturation. HID1 interacts with components of the secretory machinery, influencing the processing and release of peptide hormones, such as insulin and growth hormones. Dysregulation of HID1 has been linked to endocrine disorders and tumorigenesis. The HID1 antibody, typically developed in rabbits or mice, enables detection and localization of HID1 in tissues or cultured cells via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Its application aids in elucidating HID1’s molecular mechanisms in cellular secretion, neuroendocrine signaling, and disease pathogenesis. Research using this antibody contributes to understanding metabolic regulation, endocrine cancers, and potential therapeutic targets. Validation of antibody specificity through knockout controls or siRNA-mediated knockdown remains essential for reliable experimental outcomes.