Rabbit Polyclonal DAB2IP Antibody

The DAB2IP (Disabled homolog 2-associated protein) antibody is a crucial tool for studying the DAB2IP protein, a member of the Ras GTPase-activating protein (RasGAP) family. DAB2IP functions as a tumor suppressor by regulating key signaling pathways, including Ras/MAPK, PI3K/AKT, and NF-κB, which are involved in cell proliferation, apoptosis, and stress responses. Its gene is frequently downregulated or epigenetically silenced in various cancers, such as prostate, breast, and colorectal cancers, contributing to tumor progression and metastasis. The DAB2IP antibody enables researchers to detect and quantify protein expression levels in tissues or cell lysates via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It also aids in investigating post-translational modifications, protein-protein interactions, and subcellular localization. Structurally, DAB2IP contains a PH domain, a C2 domain, and a RasGAP-binding domain, which are critical for its regulatory functions. Studies using this antibody have highlighted its role in modulating oxidative stress responses and therapeutic resistance in cancer cells. Its development and validation have advanced understanding of DAB2IP's mechanistic contributions to oncogenesis and potential as a biomarker or therapeutic target.