Rabbit Polyclonal DICER1 Antibody

DICER1 antibodies are essential tools for studying the DICER1 protein, a critical RNase III enzyme involved in microRNA (miRNA) biogenesis. DICER1 processes precursor miRNAs into mature, functional miRNAs that regulate gene expression by targeting mRNAs for degradation or translational repression. Mutations in the DICER1 gene are linked to a hereditary cancer predisposition syndrome, DICER1 syndrome, which increases the risk of pleuropulmonary blastoma, ovarian Sertoli-Leydig cell tumors, and other rare neoplasms. Researchers use DICER1 antibodies to detect protein expression, localization, and dysregulation in both normal and pathological tissues. These antibodies are commonly applied in techniques like immunohistochemistry (IHC), Western blotting (WB), and immunofluorescence (IF) to investigate DICER1's role in development, cellular differentiation, and tumorigenesis. Specificity and validation are crucial, as DICER1 shares functional domains with other RNase III family members. Clinically, DICER1 antibodies aid in diagnosing DICER1-related tumors and understanding mechanisms underlying mutation-driven oncogenesis. Their utility extends to exploring therapeutic strategies targeting miRNA pathways, making them vital for basic research and translational oncology.