| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | DG2; DSC3; CDHF2; ARVD11; DGII/III |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human DSC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DSC2抗体的3篇参考文献及其摘要内容概括：
1. **文献名称**: *"Desmocollin 2 is essential for epidermal barrier function through desmosome-mediated junction remodeling"*
**作者**: Chen et al.
**摘要**: 本研究利用特异性DSC2抗体，通过免疫荧光和Western blot技术，揭示了DSC2在小鼠表皮屏障形成中的关键作用。实验表明，DSC2缺失导致桥粒结构异常，进而引发皮肤渗透性屏障缺陷，提示DSC2可能是遗传性皮肤病的潜在治疗靶点。
2. **文献名称**: *"DSC2 mutations contribute to arrhythmogenic right ventricular cardiomyopathy via impaired desmosomal assembly"*
**作者**: Smith et al.
**摘要**: 通过患者心肌组织样本的DSC2抗体免疫组化分析，发现DSC2基因突变导致心肌细胞桥粒蛋白表达减少和细胞间连接破坏。研究证实DSC2抗体可作为诊断工具，辅助临床鉴别致心律失常性右室心肌病(ARVC)的分子病理机制。
3. **文献名称**: *"A novel monoclonal antibody targeting DSC2 for the detection of metastatic gastric cancer"*
**作者**: Tanaka et al.
**摘要**: 报道了一种高特异性抗DSC2单克隆抗体的开发，该抗体在胃癌转移患者的循环肿瘤细胞(CTCs)检测中表现出高灵敏度。实验验证其可区分正常上皮与癌变组织，为癌症液体活检提供了新的生物标志物检测手段。
(注：以上文献信息为模拟示例，实际引用需以真实出版物为准。)
Desmocollin-2 (DSC2) is a transmembrane glycoprotein belonging to the desmocollin subfamily of cadherins, which are critical components of desmosomes—specialized cell-cell junctions that provide mechanical integrity to tissues. Expressed predominantly in epithelial and myocardial cells, DSC2 plays a vital role in maintaining tissue architecture by mediating calcium-dependent intercellular adhesion. It interacts with desmogleins and intracellular plaque proteins (e.g., plakoglobin, desmoplakin) to anchor intermediate filaments, ensuring tissue resilience against mechanical stress.
DSC2 dysfunction is linked to several pathologies. Mutations in the *DSC2* gene are associated with arrhythmogenic cardiomyopathy (ACM), a disorder characterized by fibrofatty replacement of cardiac tissue and arrhythmias. Altered DSC2 expression has also been observed in cancers, including skin, gastric, and colorectal carcinomas, where it may influence tumor progression by modulating cell adhesion and signaling pathways.
DSC2-specific antibodies are essential tools for studying desmosome biology and disease mechanisms. They enable detection of DSC2 expression and localization via techniques like immunohistochemistry, Western blotting, and immunofluorescence. In research, these antibodies help elucidate DSC2's role in tissue homeostasis, disease pathogenesis, and potential therapeutic targeting. Clinically, they aid in diagnosing desmosome-related disorders and assessing DSC2 as a biomarker in cancer prognosis. Recent studies also explore DSC2's involvement in signaling pathways, such as EGFR and Wnt, highlighting its multifaceted roles beyond structural adhesion.
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