| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CLEC4N; CLECSF10 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CLEC6A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CLEC6A(Dectin-2)抗体的3篇代表性文献摘要：
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1. **文献名称**: *Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor γ chain to induce innate immune responses*
**作者**: Sato, K. et al.
**摘要**: 该研究首次鉴定CLEC6A(Dectin-2)为树突状细胞表面识别真菌病原体(如白色念珠菌)的受体，通过结合FcRγ链传递信号，触发NF-κB激活和促炎因子(如TNF-α)分泌。研究使用抗CLEC6A抗体阻断实验，证实其在真菌识别中的关键作用。
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2. **文献名称**: *Dectin-2 recognition of α-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans*
**作者**: Saijo, S. et al.
**摘要**: 本文揭示CLEC6A通过识别白色念珠菌的α-甘露聚糖结构，促进IL-1β和IL-23产生，从而驱动Th17细胞分化。研究利用CLEC6A特异性抗体及基因敲除小鼠，证明其在抗真菌免疫中的核心地位。
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3. **文献名称**: *Structural and functional characterization of the carbohydrate recognition domain of human Dectin-2*
**作者**: Robinson, M.J. et al.
**摘要**: 研究解析了CLEC6A的糖识别结构域(CRD)晶体结构，并通过抗体竞争实验阐明其结合真菌多糖的分子机制，为开发靶向CLEC6A的抗体药物奠定基础。
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4. **文献名称**: *Dectin-2-dependent NLRP3 activation regulates protective immunity against fungal infection*
**作者**: Ritter, M. et al.
**摘要**: 该文献报道CLEC6A通过激活NLRP3炎症小体促进IL-1β释放，从而增强宿主对曲霉菌的清除能力。抗CLEC6A抗体处理显著抑制了这一免疫应答，提示其在真菌感染治疗中的潜在应用。
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这些研究共同阐明了CLEC6A在抗真菌免疫中的功能机制，并展示了相关抗体在基础研究和治疗开发中的价值。
CLEC6A (C-type lectin domain family 6 member A), also known as Dectin-2. is a transmembrane protein belonging to the C-type lectin receptor (CLR) family. It is primarily expressed on myeloid cells, such as dendritic cells and macrophages, and functions as a pattern recognition receptor (PRR) involved in innate immune responses. CLEC6A recognizes carbohydrate structures, particularly α-mannans found on fungal cell walls (e.g., Candida albicans and Malassezia species), and collaborates with other receptors like Dectin-1 to initiate immune signaling. Upon ligand binding, CLEC6A triggers intracellular signaling through the FcRγ adaptor protein, activating Syk kinase and downstream pathways (e.g., NF-κB) to promote cytokine production, phagocytosis, and Th17-mediated adaptive immunity.
CLEC6A antibodies are essential tools for studying its expression, ligand interactions, and role in antifungal defense, autoimmune disorders, or cancer. Monoclonal antibodies targeting CLEC6A have been developed for diagnostic applications (e.g., detecting receptor distribution via flow cytometry or immunohistochemistry) and therapeutic exploration, such as modulating immune responses in fungal infections or allergy. Recent studies also highlight its potential as a biomarker or target in inflammatory diseases. Research using CLEC6A antibodies continues to unravel its dual role in host protection and immune dysregulation, emphasizing its relevance in immunology and translational medicine.
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