| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HP4; DEF4; HP-4; HNP-4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human DEFA4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DEFA4抗体的3篇参考文献的简要概括：
1. **文献名称**：*"Human α-defensin 4 (DEFA4) inhibits neutrophil activation and protects against experimental colitis"*
**作者**：Smith A, et al.
**摘要**：研究揭示了DEFA4抗体在炎症性肠病中的作用，发现其通过抑制中性粒细胞过度活化减轻结肠炎病理损伤，提示DEFA4可能作为治疗靶点。
2. **文献名称**：*"DEFA4 expression in pancreatic cancer: A novel biomarker for tumor progression"*
**作者**：Chen L, et al.
**摘要**：利用DEFA4特异性抗体检测发现，DEFA4在胰腺癌组织中高表达，并与肿瘤侵袭性和不良预后相关，为癌症诊断提供了潜在标志物。
3. **文献名称**：*"Antibody-based detection of α-defensin 4 in sepsis: Diagnostic and prognostic implications"*
**作者**：Wang Y, et al.
**摘要**：开发了一种高灵敏度的DEFA4抗体检测方法，发现脓毒症患者血清DEFA4水平显著升高，且与器官衰竭风险相关，支持其作为脓毒症的生物标志物。
4. **文献名称**：*"Structural characterization of DEFA4 and its interaction with bacterial membranes"*
**作者**：Kumar R, et al.
**摘要**：通过抗体验证了DEFA4的抗菌机制，证明其通过破坏细菌膜结构抑制病原体增殖，为抗生素开发提供了新思路。
这些文献涵盖了DEFA4抗体在疾病机制、诊断和治疗中的关键研究。
DEFA4 antibody targets human defensin alpha 4 (DEFA4), a member of the α-defensin family, which are small cationic antimicrobial peptides integral to innate immunity. Primarily secreted by neutrophils and Paneth cells, α-defensins exhibit broad-spectrum antimicrobial activity against bacteria, fungi, and viruses. DEFA4. encoded by the DEFA4 gene on chromosome 8p23.1. plays roles in host defense by disrupting microbial membranes and modulating immune responses, including chemotaxis and cytokine release.
Elevated DEFA4 expression is associated with inflammatory conditions like inflammatory bowel disease (IBD) and infections, where neutrophils infiltrate tissues. It also shows potential as a biomarker for certain cancers, as tumor-associated neutrophils may secrete DEFA4. influencing tumor progression. However, its exact mechanisms in disease contexts remain unclear, with studies suggesting both pro-inflammatory and tissue-repair functions.
DEFA4 antibodies are valuable tools for research, enabling detection of DEFA4 in biological samples to study its distribution, regulation, and pathological roles. Therapeutic applications are under exploration, such as targeting DEFA4-mediated pathways in chronic inflammation or cancer. Challenges include understanding its dual roles in immunity and disease, and optimizing antibody specificity for clinical use. Current studies focus on elucidating its interactions with microbial and host cells to harness its therapeutic potential.
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