| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | SPN; NUDR; ZMYND5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human DEAF1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DEAF1抗体的3篇参考文献(示例为模拟内容，实际文献需通过数据库检索确认)：
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1. **文献名称**: *"DEAF1 regulates neuronal gene expression and differentiation in vivo"*
**作者**: Smith A, et al.
**摘要**: 研究通过DEAF1抗体进行免疫组化及Western blot，发现DEAF1在小鼠大脑皮层神经元中的特异性表达，并调控神经分化相关基因的转录，提示其在神经发育中的关键作用。
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2. **文献名称**: *"Autoantibodies against DEAF1 in rheumatoid arthritis patients"*
**作者**: Chen L, et al.
**摘要**: 利用DEAF1抗体检测类风湿性关节炎患者血清中的自身抗体，发现DEAF1蛋白异常修饰可能参与自身免疫反应，为疾病机制研究提供新方向。
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3. **文献名称**: *"DEAF1 interacts with chromatin remodeling complexes via ChIP-seq analysis"*
**作者**: Kim H, et al.
**摘要**: 通过DEAF1抗体进行染色质免疫沉淀(ChIP)，揭示DEAF1与SWI/SNF复合物协同调控靶基因的染色质结构，影响细胞周期进程。
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如需具体文献，建议在PubMed或Google Scholar中检索关键词“DEAF1 antibody”+应用方向(如Western blot/IP/IF等)。
The DEAF1 (Deformed Epidermal Autoregulatory Factor 1) antibody is a tool used to detect and study the DEAF1 protein, a transcription factor involved in regulating gene expression. DEAF1 belongs to the DEAF family of proteins, characterized by a conserved MYND domain (mediating protein-protein interactions) and a NUCR (nuclear localization) domain. It plays critical roles in embryonic development, neuronal differentiation, and synaptic function, and has been implicated in both neurodevelopmental disorders and cancer. DEAF1 binds to specific DNA sequences to either activate or repress target genes, influencing processes like cell proliferation, apoptosis, and immune responses.
Research has linked DEAF1 mutations or dysregulation to autism spectrum disorders, intellectual disability, and certain autoimmune conditions. In cancer, DEAF1 may act as a tumor suppressor or oncogene depending on context, with altered expression observed in gliomas, breast cancer, and leukemia. DEAF1 antibodies are essential for investigating its expression patterns, subcellular localization, and interactions in these contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Validation of DEAF1 antibodies is crucial due to potential cross-reactivity with homologous proteins. Commercial antibodies vary in host species, clonality, and epitope specificity, requiring careful selection based on experimental needs. Recent studies also explore DEAF1's role in stress responses and viral infection, broadening its biomedical relevance.
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