| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | AF1; EFL5; RAGS; EPLG7; GLC1M; LERK7 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human EFNA5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于EFNA5抗体的3篇代表性文献，按研究主题分类整理：
1. **文献名称**：*Ephrin-A5 Monoclonal Antibodies Inhibit Tumor Angiogenesis in Triple-Negative Breast Cancer*
**作者**：Smith J, et al.
**摘要**：研究开发了靶向EFNA5的单克隆抗体，证明其可通过阻断EphA受体信号通路抑制三阴性乳腺癌的血管生成，并降低小鼠模型中的肿瘤生长速率。
2. **文献名称**：*EFNA5 Antibody-Based Immunoassay for Early Detection of Alzheimer's Disease Biomarkers*
**作者**：Chen L, et al.
**摘要**：利用高特异性EFNA5抗体构建ELISA检测体系，发现脑脊液中EFNA5蛋白水平与阿尔茨海默病患者tau蛋白磷酸化程度显著相关，提示其作为神经退行性疾病的潜在生物标志物。
3. **文献名称**：*A Novel Ephrin-A5 Antibody Modulates Synaptic Plasticity in Hippocampal Neurons*
**作者**：Garcia-Rodriguez F, et al.
**摘要**：通过免疫共沉淀验证新型兔源多克隆抗体对EFNA5胞外域的结合能力，证明抗体干预可增强海马神经元突触可塑性，为神经损伤修复研究提供工具。
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**说明**：以上文献为模拟示例，实际研究中建议通过PubMed/Google Scholar检索真实文献。关键筛选方向包括：抗体开发(如杂交瘤技术/噬菌体展示)、治疗应用(肿瘤靶向/免疫调节)、实验工具(WB/IHC验证)等。近年研究多聚焦于EFNA5在肿瘤微环境调控及神经疾病中的抗体靶向治疗潜力。
The Ephrin-A5 (EFNA5) antibody is a research tool designed to detect and study the EFNA5 protein, a member of the ephrin family of cell-surface ligands that interact with Eph receptor tyrosine kinases. EFNA5 is a glycosylphosphatidylinositol (GPI)-anchored protein involved in cell-cell communication, mediating critical processes such as axon guidance, angiogenesis, and tissue patterning during development. Its interaction with Eph receptors triggers bidirectional signaling, influencing cell adhesion, migration, and survival. Dysregulation of EFNA5 signaling has been implicated in pathologies including cancer metastasis, neurodevelopmental disorders, and vascular diseases.
EFNA5 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to map EFNA5 expression in tissues or cultured cells. These antibodies help investigate its role in tumor microenvironment modulation, neural circuit formation, and regenerative processes. Many EFNA5 antibodies are raised in hosts like rabbits or mice, targeting specific epitopes with high specificity. Validation often includes knockout controls to ensure minimal cross-reactivity. Recent studies also explore EFNA5 as a potential therapeutic target, driving demand for reliable antibodies to assess its functional and diagnostic relevance in disease models.
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