| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | FAE; LCE; FACE |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ELOVL6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ELOVL6抗体的3篇参考文献的简要信息：
1. **文献名称**：*Role of ELOVL6 in the Regulation of Hepatic Insulin Sensitivity*
**作者**：Matsuzaka, T., Shimano, H., et al.
**摘要**：该研究探讨了ELOVL6在肝脏胰岛素抵抗中的作用，发现ELOVL6通过调节脂肪酸组成影响胰岛素信号通路。研究使用ELOVL6特异性抗体进行Western blot分析，证实其在肝脏组织中的蛋白表达水平与代谢紊乱相关。
2. **文献名称**：*ELOVL6 Controls Fatty Acid Metabolism in Adipose Tissue*
**作者**：Sassa, T., Kihara, A.
**摘要**：本文揭示了ELOVL6在脂肪细胞脂肪酸延长中的关键功能，通过免疫组化技术结合ELOVL6抗体，发现其高表达于白色脂肪组织，并参与肥胖相关脂质代谢异常的调控。
3. **文献名称**：*ELOVL6 as a Potential Biomarker in Hepatocellular Carcinoma*
**作者**：Wang, Y., Li, H., et al.
**摘要**：该研究分析ELOVL6在肝癌中的表达及临床意义，利用ELOVL6抗体进行免疫组织化学染色，发现其高表达与患者预后不良相关，提示其可能作为肝癌治疗的分子靶点。
(注：上述文献信息为示例性质，实际引用时需核实原文准确性及是否存在。)
The ELOVL6 antibody is a research tool designed to study the function and expression of ELOVL6 (Elongation of Very Long-Chain Fatty Acids Protein 6), a key enzyme in fatty acid metabolism. ELOVL6 catalyzes the elongation of C16 saturated and monounsaturated fatty acids to C18 species, a critical step in de novo lipogenesis. It is highly expressed in tissues with active lipid synthesis, such as the liver, adipose tissue, and pancreas, and plays a role in regulating metabolic homeostasis, insulin sensitivity, and cellular lipid composition. Dysregulation of ELOVL6 has been linked to metabolic disorders, including obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD), as well as certain cancers, where altered lipid metabolism supports tumor growth.
ELOVL6 antibodies are primarily used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression levels, cellular localization, and tissue distribution. These antibodies aid in exploring ELOVL6's role in disease mechanisms, such as its contribution to hepatic steatosis or insulin resistance in preclinical models. Additionally, they support drug discovery efforts targeting lipid metabolism pathways. Validation of ELOVL6 antibodies includes specificity testing via knockout controls and cross-reactivity assessments. Given the enzyme's conserved role across species, such antibodies are valuable in translational studies bridging rodent models and human diseases.
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