| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DYN2; CMT2M; DYNII; LCCS5; CMTDI1; CMTDIB; DI-CMTB |
| WB Predicted band size | 98 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human DNM2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DNM2(Dynamin 2)抗体的3篇参考文献示例，按研究领域分类简要概括：
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1. **文献名称**：*DNM2 mutations cause dominant centronuclear myopathy via loss of self-assembly and abnormal microtubule interactions*
**作者**：Cowling BS, et al.
**摘要**：本研究利用DNM2特异性抗体，通过免疫荧光和Western blot分析了DNM2突变对肌管细胞结构和自组装能力的影响，揭示了其与中心核肌病的关系。
2. **文献名称**：*A novel antibody-based biomarker for dynamin 2-related Charcot-Marie-Tooth disease*
**作者**：Sivera R, et al.
**摘要**：开发了一种针对DNM2特定表位的抗体，用于诊断Charcot-Marie-Tooth(CMT)周围神经病变，验证了其在患者外周血样本中的表达异常。
3. **文献名称**：*Dynamin 2 regulates clathrin-mediated endocytosis in cortical neurons*
**作者**：Tanabe K, et al.
**摘要**：通过DNM2抗体标记，证明DNM2在神经元突触囊泡内吞中的关键作用，并发现其功能缺失导致神经信号传递障碍。
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以上文献均聚焦于DNM2抗体在疾病机制研究或诊断工具开发中的应用，覆盖了肌肉疾病、神经病变及细胞生物学基础研究。
**Background of DNM2 Antibody**
DNM2 (Dynamin-2) is a ubiquitously expressed GTPase belonging to the dynamin family, which plays critical roles in membrane remodeling, clathrin-mediated endocytosis, intracellular vesicle trafficking, and cytoskeletal dynamics. As a key regulator of membrane fission, DNM2 facilitates the scission of vesicles from plasma membranes and organelles, ensuring proper cellular signaling, nutrient uptake, and organelle maintenance. DNM2 dysfunction is linked to several human diseases, including centronuclear myopathy (CNM), Charcot-Marie-Tooth neuropathy (CMT), and certain cancers.
DNM2 antibodies are essential tools for studying its expression, localization, and functional interactions. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate DNM2's role in cellular processes or disease mechanisms. Polyclonal and monoclonal DNM2 antibodies target specific epitopes, enabling researchers to distinguish between isoforms or post-translationally modified forms. Validation of specificity is crucial due to high homology among dynamin family members. DNM2 antibodies also aid in diagnostic research, particularly in identifying mutations associated with genetic disorders. Recent advancements in antibody engineering have improved their sensitivity and application in high-resolution imaging or therapeutic targeting.
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