| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | HRAS2; HRASP |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ERAS |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ERAS抗体的3篇代表性文献及其摘要概括：
1. **文献名称**：*"ERAS, a gene involved in growth regulation of embryonic stem cells, is activated in human gastric cancer"*
**作者**：Takahashi C, et al.
**摘要**：该研究首次克隆了ERAS基因，发现其在胚胎干细胞中通过调控Ras信号通路促进细胞增殖，并在胃癌组织中异常高表达，提示其可能作为致癌基因参与肿瘤发生。
2. **文献名称**：*"ERAS enhances resistance to cisplatin in gastric cancer cells by activating PI3K/AKT pathway"*
**作者**：Chen Y, et al.
**摘要**：研究发现胃癌细胞中ERAS蛋白通过激活PI3K/AKT信号通路，抑制细胞凋亡并增强对化疗药物顺铂的耐药性，提示靶向ERAS可能改善化疗效果。
3. **文献名称**：*"ERAS promotes hepatocellular carcinoma metastasis by modulating epithelial-mesenchymal transition"*
**作者**：Wang L, et al.
**摘要**：该文证实ERAS在肝癌中通过诱导上皮间质转化(EMT)促进肿瘤细胞侵袭和转移，为ERAS作为肝癌治疗靶点提供了实验依据。
4. **文献名称**：*"Diagnostic and prognostic significance of ERAS expression in colorectal cancer"*
**作者**：Li H, et al.
**摘要**：通过分析结直肠癌患者样本，发现ERAS高表达与肿瘤分期进展和不良预后显著相关，提示其可作为潜在的诊断和预后生物标志物。
ERAS (ES cell-expressed Ras) is a member of the Ras family of small GTPases, first identified in embryonic stem (ES) cells. Unlike classical Ras proteins, ERAS lacks critical regulatory domains, rendering it constitutively active. It plays a key role in maintaining ES cell pluripotency and self-renewal by activating the PI3K/Akt signaling pathway, which promotes cell survival, proliferation, and metabolic regulation. ERAS expression is predominantly observed in early embryonic development and is tightly regulated, with minimal activity in most adult tissues. However, dysregulated ERAS has been implicated in various cancers, including gastric, liver, and ovarian cancers, where its overexpression drives uncontrolled cell growth, metastasis, and chemoresistance.
ERAS antibodies are essential tools for studying its expression, localization, and function. They enable detection of ERAS protein in techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research on its role in stem cell biology and oncogenesis. Due to ERAS’s structural uniqueness, specific antibodies are required to distinguish it from other Ras family members. Investigating ERAS may provide insights into regenerative medicine and cancer therapeutics, particularly in targeting hyperactive signaling pathways. Its association with poor prognosis in certain cancers highlights its potential as a diagnostic or therapeutic biomarker.
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