| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DESP4; ERG25; SC4MOL |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MSMO1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MSMO1抗体的3篇模拟参考文献示例(内容为虚构，仅供参考)：
1. **文献名称**: *MSMO1 expression in hepatocellular carcinoma and its clinical significance*
**作者**: Li Y, et al.
**摘要**: 本研究利用MSMO1抗体通过免疫印迹和免疫组化技术，发现MSMO1在肝癌组织中表达显著下调，其低表达与患者预后不良相关，提示MSMO1可能作为肝癌潜在的生物标志物。
2. **文献名称**: *Role of MSMO1 in skin cholesterol biosynthesis*
**作者**: Smith J, et al.
**摘要**: 通过MSMO1特异性抗体的免疫荧光定位，揭示了该酶在表皮细胞中的亚细胞分布，并证明其功能缺陷会导致角化细胞脂质代谢异常，与鱼鳞病等皮肤病相关。
3. **文献名称**: *Genetic variants of MSMO1 and their impact on enzyme activity*
**作者**: García R, et al.
**摘要**: 研究采用MSMO1抗体检测突变体蛋白的表达水平，结合质谱分析，发现某些遗传突变会导致MSMO1酶活性丧失，进而影响胆固醇合成通路。
**注意**：以上文献为模拟示例，实际研究中需通过PubMed、Web of Science等数据库检索真实文献。建议使用关键词“MSMO1 antibody”“methylsterol monooxygenase 1”进行查询。
The MSMO1 (methylsterol monooxygenase 1) antibody targets the MSMO1 protein, also known as SC4MOL or ERG28. a key enzyme in the cholesterol biosynthesis pathway. MSMO1 catalyzes the conversion of 4α-methylsterols to 4α-carboxysterols, a critical step in the Bloch pathway of cholesterol synthesis. This enzyme localizes to the endoplasmic reticulum and is regulated by sterol levels, functioning downstream of lanosterol synthase and upstream of sterol-C4-methyl oxidase (SC4MOL). Its role in maintaining cholesterol homeostasis links it to various physiological and pathological processes, including lipid metabolism disorders, neurodegenerative diseases, and cancers.
Antibodies against MSMO1 are widely used in research to study cholesterol biosynthesis regulation, protein expression profiling, and subcellular localization. They are essential tools in Western blotting, immunohistochemistry, and immunofluorescence to investigate MSMO1’s involvement in diseases like Smith-Lemli-Opitz syndrome (SLOS), a genetic disorder linked to cholesterol synthesis defects, or cancer progression where altered cholesterol metabolism is implicated. Additionally, MSMO1 antibodies aid in exploring therapeutic targets for hypercholesterolemia and tumors reliant on endogenous cholesterol synthesis. Validated antibodies are characterized for specificity, sensitivity, and cross-reactivity across species, supporting both basic and translational studies in lipid biology and related disorders.
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