| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CMM3; PSK-J3 |
| Entrez GeneID | 1019 |
| clone | 4C5H9 |
| WB Predicted band size | 33.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of human CDK4 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SLC52A1抗体的3篇参考文献示例(文献信息为模拟生成，仅供参考)：
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1. **文献名称**: *Development of a Monoclonal Antibody Specific to Human SLC52A1 for Functional Studies in Riboflavin Transport*
**作者**: Hosoya et al.
**摘要**: 本研究开发了一种针对人源SLC52A1蛋白的单克隆抗体，通过Western blot和免疫组化验证其特异性。实验表明该抗体可有效检测肠道和肾脏组织中SLC52A1的表达，并用于研究核黄素吸收缺陷相关疾病的分子机制。
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2. **文献名称**: *SLC52A1 Expression in Neurological Disorders: An Immunohistochemical Analysis*
**作者**: Greenberg et al.
**摘要**: 利用商业化SLC52A1抗体，研究者分析了阿尔茨海默病和布朗-维阿莱特综合征患者脑组织中的蛋白分布。结果显示，SLC52A1在神经元中的表达显著降低，提示其可能与神经退行性病变中核黄素代谢异常相关。
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3. **文献名称**: *Validation of Anti-SLC52A1 Antibody for Cancer Cell Line Screening*
**作者**: Wang et al.
**摘要**: 本研究验证了一种多克隆SLC52A1抗体在多种癌细胞系中的适用性，发现其在高表达SLC52A1的胃癌细胞中特异性结合。研究进一步通过敲低实验证实抗体检测的可靠性，为靶向核黄素转运的癌症治疗提供工具支持。
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**备注**：以上文献为示例，实际引用时需根据具体研究内容检索PubMed、Web of Science等数据库获取真实文献信息。
The SLC52A1 antibody is a tool used to study the solute carrier family 52 member 1 (SLC52A1), a gene encoding riboflavin transporter RFVT1. This transporter is critical for cellular uptake of riboflavin (vitamin B2), a precursor for flavin coenzymes (FAD and FMN) essential in redox reactions and energy metabolism. SLC52A1 is primarily expressed in the intestine, placenta, and kidneys, facilitating dietary riboflavin absorption and systemic distribution. Mutations in SLC52A1 are linked to Brown-Vialetto-Van Laere syndrome (BVVLS), a rare autosomal recessive disorder characterized by neurodegeneration, sensorineural hearing loss, and respiratory insufficiency due to impaired riboflavin transport.
SLC52A1 antibodies enable researchers to detect RFVT1 protein expression, localization, and abundance in tissues or cell lines. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate RFVT1's role in health and disease. Such studies help elucidate mechanisms of riboflavin deficiency disorders and validate therapeutic strategies, including high-dose riboflavin supplementation. Additionally, these antibodies aid in exploring SLC52A1 regulation under physiological or pathological conditions, such as inflammation or metabolic stress. By identifying RFVT1 dysfunction, researchers can better understand its contribution to BVVLS and other conditions linked to flavoprotein deficiencies, offering insights into personalized treatment approaches.
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