| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | GDH2; GPDM; mGPDH |
| WB Predicted band size | 81 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GPD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GPD2抗体的3篇参考文献(示例基于假设性文献，实际文献需通过数据库检索确认)：
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1. **文献名称**：*Mitochondrial GPD2 Antibody Development and Its Application in Metabolic Syndrome Models*
**作者**：Smith J, et al.
**摘要**：本研究开发了一种兔源多克隆GPD2抗体，通过免疫印迹和免疫组化验证其特异性，发现GPD2在肥胖小鼠肝脏中线粒体表达显著上调，提示其与脂质代谢异常相关。
2. **文献名称**：*GPD2 Expression in Pancreatic β-Cells: Role in Insulin Secretion*
**作者**：Chen L, et al.
**摘要**：利用特异性GPD2抗体，研究发现GPD2通过调节甘油磷酸穿梭影响胰岛β细胞ATP生成，进而调控葡萄糖刺激的胰岛素分泌，为糖尿病机制提供了新视角。
3. **文献名称**：*Antibody-Based Profiling of GPD2 in Human Colorectal Cancer*
**作者**：Wang Y, et al.
**摘要**：通过商业化GPD2抗体分析结直肠癌组织，发现GPD2高表达与肿瘤糖酵解活性和患者预后不良相关，提示其作为潜在治疗靶点的可能性。
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如需具体文献，建议在 **PubMed** 或 **Google Scholar** 中检索关键词“GPD2 antibody”或“GPD2 mitochondrial localization”获取最新研究。
**Background of GPD2 Antibody**
Glycerol-3-phosphate dehydrogenase 2 (GPD2) is a mitochondrial enzyme critical for the glycerol phosphate shuttle, a metabolic pathway facilitating the transfer of reducing equivalents (NADH) from the cytoplasm into mitochondria for ATP production. This enzyme catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, linking carbohydrate and lipid metabolism. Dysregulation of GPD2 has been implicated in metabolic disorders, including diabetes, obesity, and non-alcoholic fatty liver disease, due to its role in energy homeostasis.
GPD2 antibodies are essential tools for studying the enzyme's expression, localization, and function in cellular and disease contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess GPD2 protein levels in tissues or cell lines. Recent research highlights GPD2's potential involvement in cancer, where altered expression may influence tumor cell proliferation and survival via metabolic reprogramming.
These antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes of human or murine GPD2. Their validation includes specificity checks using knockout models or siRNA-mediated silencing. By enabling precise detection of GPD2. these antibodies support investigations into metabolic diseases, cancer biology, and therapeutic targeting of mitochondrial energetics.
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