| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CD131; IL3RB; IL5RB; SMDP5; CDw131 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CSF2RB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CSF2RB抗体的示例参考文献(注：以下内容为模拟示例，非真实文献)：
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1. **标题**: *CSF2RB Antibody as a Novel Biomarker in Myeloid Leukemia*
**作者**: Smith A, et al.
**摘要**: 该研究开发了针对CSF2RB胞外结构域的单克隆抗体，验证了其在急性髓系白血病(AML)患者外周血中的高表达，并证明其可作为预后标志物及潜在治疗靶点。
2. **标题**: *Role of CSF2RB Signaling in Autoimmune Inflammation*
**作者**: Chen L, et al.
**摘要**: 通过CSF2RB特异性抗体阻断实验，揭示了该受体在Th17细胞分化中的关键作用，为类风湿性关节炎等自身免疫疾病提供了新的机制解释。
3. **标题**: *Optimization of CSF2RB Antibody for Flow Cytometry Applications*
**作者**: Tanaka K, et al.
**摘要**: 报道了一种高灵敏度抗CSF2RB抗体的优化方案，成功用于流式细胞术检测小鼠骨髓中粒细胞-巨噬细胞祖细胞(GMP)的亚群分布。
4. **标题**: *CSF2RB Antibody-Based Therapeutic Strategy in Pulmonary Fibrosis*
**作者**: Müller R, et al.
**摘要**: 利用人源化抗CSF2RB抗体抑制肺泡巨噬细胞的异常激活，在小鼠模型中显著减缓肺纤维化进程，提示其临床转化潜力。
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**说明**：以上文献为虚构示例，实际研究中建议通过PubMed或Web of Science等数据库检索真实文献。研究关键词可包括：CSF2RB antibody, GM-CSF receptor beta, IL-3/IL-5/GM-CSF receptor signaling。
The CSF2RB antibody targets the CSF2RB protein, a critical component of the cytokine receptor family that mediates signaling for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-5 (IL-5). CSF2RB, also known as CD131 or β common chain (βc), is a transmembrane protein that pairs with ligand-specific α-subunits to form high-affinity receptor complexes. These receptors play pivotal roles in hematopoiesis, immune cell differentiation, and inflammatory responses by activating downstream pathways such as JAK-STAT, MAPK, and PI3K/AKT.
CSF2RB antibodies are primarily used in research to investigate receptor function, signaling mechanisms, and dysregulation in diseases like leukemia, asthma, and autoimmune disorders. Aberrant CSF2RB signaling has been linked to hyperproliferative conditions, including myeloproliferative neoplasms, due to mutations or overexpression. Researchers employ CSF2RB antibodies in techniques like Western blotting, flow cytometry, and immunohistochemistry to study protein expression, localization, and interactions. Therapeutic applications are also being explored, with neutralizing antibodies tested for their ability to block pathogenic cytokine signaling. The development of CSF2RB-targeting agents highlights its potential as a biomarker or therapeutic target in oncology and immunology.
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