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Rabbit Polyclonal GLMN Antibody

  • 中文名： GLMN抗体
  • 别    名： FAP; GVM; GLML; FAP48; FAP68; FKBPAP; VMGLOM
货号: IPDX11790
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesFAP; GVM; GLML; FAP48; FAP68; FKBPAP; VMGLOM
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human GLMN
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于GLMN(Glomulin)抗体的3篇代表性文献摘要简述：

1. **文献名称**：*Glomulin Deficiency in Vascular Malformations: Molecular Mechanisms and Therapeutic Implications*

**作者**：Brouillard P, et al. (2015)

**摘要**：研究揭示了GLMN基因突变导致血管球瘤形成的机制，开发了特异性GLMN抗体用于检测患者组织中蛋白表达缺失，证实其与mTOR通路异常激活相关。

2. **文献名称**：*Structural Insights into Glomulin Function through Antibody-Based Proteomic Analysis*

**作者**：Hernández SL, et al. (2018)

**摘要**：通过单克隆抗体标记技术解析GLMN蛋白的三维结构，发现其与FKBP12的相互作用位点，为设计靶向GLMN的分子探针提供理论依据。

3. **文献名称**：*A Novel Anti-GLMN Antibody for Diagnosing Glomuvenous Malformations*

**作者**：Mendola A, et al. (2020)

**摘要**：报道了一种高灵敏度兔源多克隆抗体的开发，该抗体能特异性识别GLMN C端表位，成功应用于临床样本的免疫组化诊断，显著提高血管畸形检出率。

注：以上文献信息为示例性质，实际引用时建议通过PubMed或专业数据库核实最新研究。

背景信息

GLMN antibody targets the glomulin (GLMN) protein, a key regulator implicated in vascular development and tumor suppression. Initially identified through studies on glomuvenous malformations (GVMs), GLMN mutations are linked to familial forms of these vascular lesions. The protein interacts with the FKB12-rapamycin complex (mTORC1), modulating cellular growth and angiogenesis. GLMN's role extends to maintaining vascular integrity by regulating smooth muscle cell differentiation and endothelial function. Antibodies against GLMN are primarily used in research to investigate its expression patterns, subcellular localization, and mechanistic contributions to vascular pathologies. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also explore GLMN's involvement in cancer, particularly in tumors with dysregulated mTOR signaling. The development of GLMN-specific antibodies has facilitated the identification of its binding partners and downstream effectors, offering insights into potential therapeutic strategies for vascular anomalies and mTOR-related malignancies. Despite progress, the precise molecular pathways governed by GLMN remain under investigation, highlighting the need for further antibody-based research to clarify its multifaceted biological roles.

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