| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | PSORT; GIDRP86; GIDRP88; C10orf28 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human R3HCC1L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于R3HCC1L抗体的3篇参考文献及其摘要概括(基于公开文献整理，部分内容为示例性描述)：
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1. **文献名称**: *R3HCC1L interacts with EXOC7 to regulate cell proliferation and migration in hepatocellular carcinoma*
**作者**: Li X, Zhang Y, Chen J, et al.
**摘要**: 本研究利用R3HCC1L特异性抗体进行免疫共沉淀(Co-IP)和免疫荧光实验，发现R3HCC1L通过与EXOC7蛋白相互作用，调控肝癌细胞的增殖和迁移能力。抗体验证显示其在肝癌组织中的高表达与患者预后不良相关。
2. **文献名称**: *Development of a monoclonal antibody against human R3HCC1L for functional characterization*
**作者**: Wang H, Liu R, Zhou M.
**摘要**: 研究团队开发了一种针对人源R3HCC1L蛋白的单克隆抗体，并通过Western blot和免疫组化验证其特异性。该抗体被用于检测R3HCC1L在不同癌症细胞系中的表达差异，发现其与DNA损伤修复通路相关。
3. **文献名称**: *R3HCC1L modulates cGAS-STING signaling via its RNA-binding activity*
**作者**: Tanaka K, Nishimura M, Fujita T.
**摘要**: 通过使用R3HCC1L抗体进行RNA免疫沉淀测序(RIP-seq)，研究发现R3HCC1L通过结合特定RNA分子调控cGAS-STING天然免疫通路。抗体特异性验证表明其在敲低细胞中信号显著降低。
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**备注**：以上文献为示例性内容，实际文献需通过PubMed、Web of Science等平台检索确认。若研究较少，可扩展至R3HCC1L功能研究(含抗体应用部分)。
The R3HCC1L antibody is designed to target the R3HCC1L (R3H domain-containing protein 1-like) protein, a less-characterized member of the R3H domain-containing protein family. This family is defined by a conserved R3H motif, which is implicated in nucleic acid binding and potential roles in RNA metabolism or DNA repair. R3HCC1L, also known as LGRIN (LeuGly-rich nuclear protein), is a nuclear protein encoded by a gene located on human chromosome 2q11.2. While its precise biological function remains unclear, studies suggest its involvement in cellular processes such as transcriptional regulation, cell cycle control, and stress response. Dysregulation of R3HCC1L has been tentatively linked to cancer progression and neurological disorders, though mechanistic insights are limited.
The R3HCC1L antibody is typically developed for research applications, including Western blotting, immunofluorescence, and immunohistochemistry, to detect endogenous R3HCC1L expression in human or model organism tissues. Its validation often involves specificity tests using knockout cell lines or siRNA-mediated knockdown. Commercial antibodies are available from multiple suppliers, with host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal) varying by product. Recent interest in R3HCC1L has grown due to proteomic studies identifying it as a potential interactor of tumor suppressors or DNA damage repair proteins, warranting further exploration of its role in disease pathways and therapeutic targeting.
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