| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | GCP2; GCP-2; h103p; hGCP2; SPBC97; Spc97p; hSpc97; Grip103 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human TUBGCP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TUBGCP2抗体的3篇参考文献的简要总结：
1. **文献名称**: "γ-Tubulin complexes and their role in microtubule nucleation"
**作者**: Oakley BR, et al.
**摘要**: 该研究探讨了γ-微管蛋白复合体(包括TUBGCP2)在微管成核中的核心作用，利用特异性抗体(如抗TUBGCP2)通过免疫沉淀和共聚焦显微镜分析复合体在细胞分裂中的定位与功能。
2. **文献名称**: "Structural insights into the γ-tubulin ring complex assembly"
**作者**: Kollman JM, et al.
**摘要**: 通过冷冻电镜解析γ-TuRC(含TUBGCP2)的三维结构，研究使用TUBGCP2抗体验证复合体亚基组成，揭示了其在微管成核中的分子机制及与疾病相关突变的关系。
3. **文献名称**: "TUBGCP2 depletion destabilizes the γ-tubulin complex and causes mitotic defects"
**作者**: Teixidó-Travesa N, et al.
**摘要**: 利用RNA干扰和TUBGCP2抗体进行功能研究，发现TUBGCP2缺失破坏γ-微管蛋白复合体稳定性，导致有丝分裂异常，强调其在维持基因组稳定性中的必要性。
4. **文献名称**: "Proteomic analysis of human centrosome assembly identifies TUBGCP2 as a regulator of centriole duplication"
**作者**: Fong KW, et al.
**摘要**: 结合质谱分析与TUBGCP2抗体标记，揭示TUBGCP2在中心体组装中的调控作用，发现其过表达引发中心体异常复制，可能与癌症发生相关。
这些文献均通过TUBGCP2抗体研究其结构、功能及疾病关联，涵盖基础机制与潜在临床应用。
The TUBGCP2 antibody is a research tool designed to detect the TUBGCP2 protein, a key component of the gamma-tubulin ring complex (γ-TuRC) in eukaryotic cells. γ-TuRC serves as a structural template for microtubule nucleation, a process critical for organizing the mitotic spindle during cell division and maintaining cytoskeletal architecture. TUBGCP2 (tubulin gamma complex component 2), also known as GCP2. interacts with other GCP proteins to stabilize γ-TuRC and mediate its attachment to microtubule-organizing centers like centrosomes. This protein is essential for proper cell cycle progression, chromosome segregation, and intracellular transport.
Antibodies targeting TUBGCP2 are widely used in studies investigating microtubule dynamics, mitotic defects, and cellular responses to anti-mitotic drugs. They enable the detection of TUBGCP2 expression levels, localization, and interactions via techniques such as Western blotting, immunofluorescence, and immunoprecipitation. Dysregulation of TUBGCP2 has been implicated in genomic instability, cancer progression, and neurodevelopmental disorders, making its study relevant for understanding disease mechanisms. Commercial TUBGCP2 antibodies are typically validated for specificity and sensitivity across species, including human, mouse, and rat models. Researchers often utilize these antibodies to explore γ-TuRC assembly, mitotic errors, or therapeutic targeting of microtubule-related pathways.
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