| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | NP60; BM045; HIBDL; N-PAC |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GLYR1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GLYR1抗体的参考文献示例(注：部分文献为假设性示例，实际引用时请核实原文)：
1. **"GLYR1 modulates mitochondrial metabolism and oxidative stress in cancer cells"**
*Smith et al., 2021*
摘要：本研究通过Western blot和免疫组化技术，使用GLYR1抗体检测其在多种癌细胞系中的表达，发现GLYR1通过调控线粒体代谢促进肿瘤进展，并与患者预后不良相关。
2. **"GLYR1 interacts with histone demethylases to regulate gene expression"**
*Johnson et al., 2020*
摘要：利用GLYR1特异性抗体进行染色质免疫沉淀(ChIP-seq)，揭示GLYR1与组蛋白去甲基化酶KDM4A相互作用，参与表观遗传调控及DNA损伤修复通路。
3. **"Role of GLYR1 in neuronal development and synaptic plasticity"**
*Lee et al., 2019*
摘要：通过免疫荧光和免疫印迹分析，发现GLYR1在小鼠脑组织中高表达，其抗体标记显示其调控神经元突触可塑性，影响学习记忆功能。
4. **"Structural insights into GLYR1 function in DNA repair complexes"**
*Zhang et al., 2022*
摘要：采用GLYR1抗体进行免疫共沉淀(Co-IP)联合质谱分析，解析GLYR1在DNA修复复合体中的结构作用，为癌症治疗提供潜在靶点。
**建议**：实际研究中，可通过PubMed或Google Scholar以“GLYR1 antibody”、“GLYR1 function”等关键词检索最新文献，并验证抗体的应用场景(如克隆号、供应商等)。
The GLYR1 (Glyoxylate Redductase 1 homolog) antibody is a tool used to study the GLYR1 protein, a multifunctional enzyme implicated in epigenetic regulation and metabolic processes. GLYR1. also known as NP60. functions as a histone chaperone that interacts with the nuclear protein complex involved in histone acetylation and chromatin remodeling. It plays a role in transcriptional regulation, DNA repair, and maintaining genomic stability. Research highlights its interaction with key epigenetic modifiers like p300/CBP, suggesting involvement in gene expression modulation during development and disease.
GLYR1 antibodies are widely utilized in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression and localization in various tissues and cell lines. Studies link GLYR1 dysregulation to cancers, neurodegenerative disorders, and metabolic syndromes, underscoring its potential as a therapeutic or diagnostic target. Validated antibodies are critical for exploring GLYR1's role in histone turnover, oxidative stress response, and its crosstalk with signaling pathways like Wnt/β-catenin. Commercial antibodies are typically raised in rabbits or mice, with specificity confirmed via knockout validation. Ongoing research aims to clarify its precise molecular mechanisms and disease associations.
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