| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HEL55; Hsp20; PPP1R91 |
| WB Predicted band size | 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human HSPB6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HSPB6(HSP20)抗体的3篇文献示例，包含文献名称、作者及摘要概述：
1. **文献名称**：*HSP20 protects the heart against ischemia-reperfusion injury via modulation of ROS production*
**作者**：Fan GC, et al.
**摘要**：该研究利用HSPB6抗体检测小鼠心脏组织中HSP20的表达，发现其通过抑制活性氧(ROS)生成减轻心肌缺血再灌注损伤，揭示了HSP20在心血管保护中的作用机制。
2. **文献名称**：*Phosphorylation-dependent interaction of HSPB6 with cytoskeletal proteins in smooth muscle cells*
**作者**：Dreiza CM, et al.
**摘要**：通过HSPB6抗体进行免疫共沉淀实验，证明磷酸化的HSP20与肌动蛋白结合，调节平滑肌细胞收缩功能，为血管张力调控提供了分子依据。
3. **文献名称**：*HSPB6 expression in human tumors: correlation with cancer progression and prognosis*
**作者**：Lee JS, et al.
**摘要**：使用HSPB6抗体分析多种癌症组织样本，发现HSP20低表达与肿瘤侵袭性和不良预后相关，提示其可能作为癌症治疗的潜在靶点。
注：以上文献信息为示例，实际引用时需核对真实发表的论文及细节。
The heat shock protein beta-6 (HSPB6), also known as HSP20. is a member of the small heat shock protein (sHSP) family characterized by a conserved α-crystallin domain. With a molecular weight of approximately 17 kDa, HSPB6 is ubiquitously expressed but enriched in smooth muscle, cardiac tissue, and skeletal muscle. It plays a regulatory role in stress response, cell survival, and cytoskeletal organization. Notably, HSPB6 is involved in modulating vascular relaxation through interactions with nitric oxide signaling pathways and exhibits cardioprotective effects by preventing apoptosis and improving contractile function under ischemic conditions. Dysregulation of HSPB6 has been linked to cardiovascular diseases, neurodegenerative disorders, and cancer, making it a target for therapeutic research.
HSPB6 antibodies are essential tools for detecting and quantifying this protein in experimental settings. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study HSPB6 expression, localization, and interactions under physiological or pathological conditions. Polyclonal antibodies offer broad epitope recognition, while monoclonal antibodies provide high specificity. Validated antibodies undergo rigorous testing for cross-reactivity, often using knockout cell lines or peptide blocking assays. Researchers rely on HSPB6 antibodies to explore its role in stress adaptation, disease mechanisms, and potential as a biomarker or therapeutic target.
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