| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131 |
| WB Predicted band size | 70 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human NRG1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NRG1抗体的3篇参考文献示例，涵盖不同研究领域：
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1. **文献名称**：*Targeting NRG1/HER3 Signaling with a Monoclonal Antibody Inhibits Tumor Growth in HER2-Positive Cancers*
**作者**：Yarden Y, et al.
**摘要内容**：该研究开发了一种靶向NRG1的单克隆抗体，通过阻断其与HER3受体的结合，抑制下游信号通路(如PI3K/AKT)。在HER2阳性乳腺癌模型中，该抗体显著降低肿瘤生长和转移，提示其在联合靶向治疗中的潜力。
2. **文献名称**：*Neuregulin-1 Antibody as a Diagnostic Tool for Neurodegenerative Disorders*
**作者**：Mei L, et al.
**摘要内容**：研究者利用高特异性抗NRG1抗体检测脑脊液中的NRG1异构体水平，发现阿尔茨海默病患者中NRG1的异常剪切形式显著升高。该抗体为神经退行性疾病的早期诊断提供了潜在生物标志物。
3. **文献名称**：*Anti-NRG1 Therapy Attenuates Cardiac Hypertrophy in a Rodent Model of Heart Failure*
**作者**：Zhao YY, et al.
**摘要内容**：通过注射中和性NRG1抗体，研究团队在小鼠心力衰竭模型中观察到心肌肥厚程度减轻。结果表明，NRG1/ErbB4信号通路在病理性心脏重构中起关键作用，抗体干预可能成为治疗策略。
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**备注**：以上文献为示例性概括，实际研究需根据具体数据库检索(如PubMed)。若需真实文献，建议通过关键词“NRG1 antibody”、“Neuregulin-1 therapeutic”等在学术平台进一步筛选。
Neuregulin-1 (NRG1) antibodies are tools used to study the NRG1 signaling pathway, which plays critical roles in cellular processes such as proliferation, differentiation, and survival. NRG1 belongs to the epidermal growth factor (EGF) family and functions by binding to ErbB receptor tyrosine kinases, particularly ErbB3 and ErbB4. triggering downstream signaling cascades. This pathway is essential in developing and maintaining the nervous system, heart, and mammary glands. Dysregulation of NRG1 signaling has been implicated in various diseases, including cancer, schizophrenia, and cardiovascular disorders.
NRG1 antibodies are widely utilized in research to detect and quantify NRG1 isoforms (e.g., NRG1α and NRG1β) in tissues or cell lines via techniques like Western blotting, immunohistochemistry, and ELISA. They help elucidate NRG1's spatial and temporal expression patterns, shedding light on its physiological and pathological roles. For instance, in oncology, these antibodies aid in studying NRG1's dual role as both a tumor suppressor and promoter, depending on context and isoform expression. In neuroscience, they explore NRG1's involvement in synaptic plasticity and its potential link to psychiatric disorders.
Therapeutic antibodies targeting NRG1 or its receptors are under investigation, particularly in cancers with NRG1 gene fusions, which drive oncogenic signaling. However, challenges remain in specificity and minimizing off-target effects. Overall, NRG1 antibodies serve as vital reagents for unraveling the complexities of this multifaceted signaling axis and advancing translational applications.
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