| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | HOX2; HOX2F; HOX-2.6 |
| WB Predicted band size | 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXB4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOXB4抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*HOXB4-induced expansion of adult hematopoietic stem cells ex vivo*
**作者**：Antonchuk J, et al.
**摘要**：研究通过HOXB4蛋白过表达促进造血干细胞的体外扩增，使用HOXB4抗体验证其表达水平，证实其在干细胞再生医学中的潜在应用。
2. **文献名称**：*Differential expression of HOXB4 in hematopoietic cell lineages and its role in leukemia*
**作者**：Sauvageau G, et al.
**摘要**：通过HOXB4抗体检测其在正常造血细胞和白血病细胞中的表达差异，发现HOXB4异常表达与白血病的发生发展相关。
3. **文献名称**：*HOXB4 as a regulator of hematopoietic stem cell self-renewal*
**作者**：Thorsteinsdottir U, et al.
**摘要**：利用HOXB4抗体分析其在干细胞自我更新中的调控机制，揭示其通过特定信号通路维持干细胞功能的分子基础。
4. **文献名称**：*Monoclonal antibody production for HOXB4 protein characterization*
**作者**：Fan R, et al.
**摘要**：报道一种特异性HOXB4单克隆抗体的开发，验证其在免疫印迹和免疫荧光中的应用，为HOXB4功能研究提供可靠工具。
(注：以上文献信息为示例，实际引用需核对原文准确性。)
HOXB4 antibody is a research tool designed to detect HOXB4. a member of the homeobox (HOX) gene family, which plays critical roles in embryonic development and cellular differentiation. HOX genes encode transcription factors that regulate body patterning and organogenesis, with HOXB4 specifically implicated in hematopoiesis. Studies highlight its function in enhancing hematopoietic stem cell (HSC) self-renewal while maintaining differentiation potential, making it a focus in regenerative medicine and stem cell expansion research.
HOXB4 antibodies are widely used in techniques like Western blotting, immunofluorescence, and flow cytometry to study HOXB4 protein expression, localization, and interactions. These antibodies help investigate its role in normal hematopoiesis, leukemogenesis (where HOXB4 dysregulation is linked to certain leukemias), and potential therapeutic applications, such as ex vivo HSC expansion for transplantation.
The development and validation of HOXB4 antibodies require careful specificity testing due to high homology among HOX family proteins. Monoclonal and polyclonal variants are available, with selection depending on experimental needs. Recent studies also explore HOXB4's impact beyond hematopoiesis, including neural and cancer stem cell biology, broadening the antibody's utility in diverse research contexts.
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