Rabbit Polyclonal MAGEB18 Antibody

The MAGEB18 antibody targets a protein encoded by the melanoma-associated antigen (MAGE) B18 gene, part of the MAGE gene family. MAGE proteins are classified into two groups: Type I (cancer-testis antigens), expressed primarily in germ cells and certain cancers, and Type II, broadly expressed in normal tissues. MAGEB18 belongs to the Type I MAGE-B subfamily, which includes genes clustered on the X chromosome. These proteins are characterized by a conserved MAGE homology domain and are implicated in tumorigenesis, though their precise biological roles remain under investigation. MAGEB18 expression is typically restricted to reproductive tissues but becomes aberrantly activated in various cancers, including melanoma, lung, and breast malignancies, making it a potential tumor-specific biomarker. Antibodies against MAGEB18 are primarily utilized in research to study its expression patterns, intracellular interactions, and oncogenic mechanisms. They are also explored for diagnostic applications (e.g., immunohistochemistry) and therapeutic strategies, such as cancer vaccines or CAR-T cell therapies targeting MAGEB18-positive tumors. However, challenges persist, including limited understanding of its functional pathways and variability in tumor expression. Ongoing studies aim to clarify its role in cancer progression and immune evasion, with the goal of optimizing MAGEB18-directed immunotherapies.