Rabbit Polyclonal NLRP6 Antibody

NLRP6 (NOD-like receptor family pyrin domain-containing 6) is a member of the NLR family of pattern recognition receptors involved in innate immunity. It plays a critical role in forming inflammasome complexes, which regulate inflammatory responses by activating caspase-1 and processing pro-inflammatory cytokines like IL-18 and IL-1β. NLRP6 is predominantly expressed in epithelial cells of the gut, liver, and other mucosal tissues, where it modulates host-microbiome interactions, antimicrobial defense, and tissue repair. Studies highlight its dual role in inflammation, showing both protective and pathogenic effects depending on context. For instance, NLRP6 deficiency in mice has been linked to dysregulated gut microbiota, exacerbated colitis, altered metabolic syndromes, and susceptibility to hepatic steatosis or infections. NLRP6 antibodies are essential tools for detecting protein expression, localization, and functional studies. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore NLRP6's involvement in diseases such as inflammatory bowel disease (IBD), non-alcoholic fatty liver disease (NAFLD), and cancer. However, research on NLRP6 remains challenging due to its tissue-specific roles, complex crosstalk with microbial metabolites, and contradictory findings across different experimental models. Reliable antibodies are critical for clarifying its mechanistic contributions to immunity and disease.